Compound

7alpha,25-dihydroxycholesterol

CHEBI:37623ChEBI

Structure

2D depiction · 3D model shown

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A generated conformer of 7alpha,25-dihydroxycholesterol — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C27H46O3
Mass: 418.662 g/mol
Charge: 0
InChIKey: BQMSKLCEWBSPPY-IKVTXIKFSA-N
SMILES: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCCC(C)(C)O)[C@]1([H])[C@H](O)C=C1C[C@@H](O)CC[C@@]12C
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

HSD3B7ProteinUNIPROT:Q9H2F3substrate ofInferred only20 paths10 endpoints

What the reference databases state

Chemical structure

7alpha,25-dihydroxycholesterol has the functional parent cholesterolCompoundChEBI CHEBI:37623Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: 7alpha,25-dihydroxycholesterol · Sources: Human-GEM, Rhea

Order

25-hydroxycholesterol is converted to 7alpha,25-dihydroxycholesterolCompoundHuman-GEM MAR01777Inferred only
7alpha,25-dihydroxycholesterol is converted to 7alpha,25-dihydroxy-4-cholesten-3-oneCompoundHuman-GEM MAR01778Inferred only
7alpha,25-dihydroxycholesterol is converted to 7alpha,25-dihydroxy-4-cholesten-3-oneCompoundRhea RHEA:47156Inferred only
7alpha,25-dihydroxy-4-cholesten-3-one is converted to 7alpha,25-dihydroxycholesterolCompoundHuman-GEM MAR01778Inferred only
7alpha,25-dihydroxycholesterol is a substrate of HSD3B7ProteinRhea RHEA:47156Inferred only
7alpha,25-dihydroxycholesterol is a substrate of HSD3B7ProteinHuman-GEM MAR01778Inferred only

Reactions

7 reactions

7alpha,25-dihydroxycholesterol
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR00721CC BY 4.0Reference data
25-hydroxycholesterol+proton+NADPH(4-)+dioxygen7alpha,25-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP7B1
Reaction pageLeft to rightBalancedEC 1.14.14.29endoplasmic reticulum
Human-GEM MAR01777CC BY 4.0Reference data
7alpha,25-dihydroxy-4-cholesten-3-one+proton+NADH(2-)7alpha,25-dihydroxycholesterol+NAD(+)
Catalysed by HSD3B7
Reaction pageReversibleBalancedEC 1.1.1.181endoplasmic reticulum
Human-GEM MAR01778CC BY 4.0Reference data
7alpha,25-dihydroxycholesterol7alpha,25-dihydroxycholesterol
Reaction pageReversibleBalancedEC 6.2.1.7endoplasmic reticulum, cytosol
Human-GEM MAR01851CC BY 4.0Reference data
7alpha,25-dihydroxycholesterol7alpha,25-dihydroxycholesterol
Reaction pageReversibleBalancedEC 6.2.1.7cytosol, extracellular space
Human-GEM MAR01856CC BY 4.0Reference data
25-hydroxycholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen7alpha,25-dihydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP7B1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:24308CC BY 4.0Reference data
7alpha,25-dihydroxycholesterol+NAD(1-)7alpha,25-dihydroxy-4-cholesten-3-one+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:47156CC BY 4.0Reference data

Other names

6 names

Resolves to: 7alpha,25-dihydroxycholesterol

Also called: 3beta,7alpha,25-Trihydroxycholest-5-ene5-Cholesten-3beta,7alpha,25-triolcholest-5-en-3beta,7alpha,25-triolCholest-5-ene-3beta,7alpha,25-triolST 27:1;O3
Systematic name: cholest-5-ene-3β,7α,25-triol