3-sulfino-L-alanine

Three steps

• CHEBI:28701Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC25A12, SLC25A13, NAT8L, ACAA1 and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A12, SLC25A13, AGXT2, SCLYmitochondrial matrix, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC25A12, SLC25A13, SLC7A13, CTHmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• a dicarboxylateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC1A7, SLC1A3 and 8 moremitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• Phe-tRNA(Phe)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, FARSB and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• Trp-tRNA(Trp)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, WARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• Gln-tRNA(Gln)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, QARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• Asn-tRNA(Asn)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC25A12, SLC25A13, ASNS, NARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 24 routes

• D-aspartateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A12, SLC25A13, SLC1A7, SLC1A3 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A3 and 2 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:30249Reach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, IDO1 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• oxalateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by SLC25A12, SLC25A13, GOT2, CSmitochondrial matrix, cytosolOne of 2 routes

• butyric acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by GOT1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by GOT1, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. L-Serine:pyruvate aminotransferase

  Catalysed by GOT1, AGXTcytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  3. (S)-dihydroorotate amidohydrolase

  Catalysed by SLC25A12, SLC25A13, CADmitochondrial matrix, cytosolOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A12, SLC25A13, GOT2mitochondrial matrix, cytosol

• (2R,3R)-tartrateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC25A12, SLC25A13, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-lysineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, SLC7A7mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-oxopropanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by GOT1, AGXT2cytosolOne of 2 routes

• thiosulfateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. 3-mercaptopyruvate:sulfide sulfurtransferase

  Catalysed by GOT1, MPST, TSTcytosolOne of 9 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A12, SLC25A13, SLC7A13, IL4I1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• serotoninReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, SLC1A7, SLC1A3 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• D-cysteineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC25A12, SLC25A13, AGXT2, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. D-serine = pyruvate + NH4(+)

  Catalysed by GOT1, SRRcytosolOne of 11 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

  Catalysed by SLC25A12, SLC25A13, SLC7A13, TATmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• taurocholateReach from here →
  1. 3-sulfino-L-alanine carboxy-lyase
  2. Hypotaurine Oxidase, Extracellular
  3. Choloyl-CoA:glycine N-choloyltransferase

  Catalysed by GAD1, CSAD, BAATcytosol, extracellular space, peroxisomeOne of 3 routes

• taurodeoxycholateReach from here →
  1. 3-sulfino-L-alanine carboxy-lyase
  2. Hypotaurine Oxidase, Extracellular
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by GAD1, CSAD, BAATcytosol, extracellular spaceOne of 2 routes

• (R)-lactic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by GOT1, LDHDcytosol

• (S)-lactic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by GOT1, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by GOT1, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. pyruvate kinase (dTDP)

  Catalysed by GOT1, PKM, PKLRcytosolOne of 3 routes

• N-acetyl-beta-neuraminic acidReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by GOT1, NPLcytosol

• L-ornithineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and ornithine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNS, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 25 routes

• gamma-Glu-AlaReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC25A12, SLC25A13, AGXT2, GGT1 and 5 moremitochondrial matrix, cytosol, extracellular space

• a 3-acylpyruvateReach from here →
  1. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase
  2. 3-sulfinylpyruvic acid hydrolysis
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by GOT1, FAHD1cytosol

• glycineReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by SLC25A12, SLC25A13, ASNSmitochondrial matrix, cytosol, extracellular spaceOne of 57 routes

• (R)-methylmalonyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC25A12, SLC25A13, NAT8L, ALDH6A1mitochondrial matrix, cytosolOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosol

• 3'-dephospho-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC25A12, SLC25A13, NAT8L, ACP2mitochondrial matrix, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC25A12, SLC25A13, NAT8Lmitochondrial matrix, cytosolOne of 3 routes