phosphoenolpyruvate

Three steps

• L-cystineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by PCK1, PCK2, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• CHEBI:16284Reach from here →
  1. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  3. dATP:pyruvate 2-O-phosphotransferase

  Catalysed by ENO4, ENO1, ENO2, ENO3 and 2 morecytosolOne of 3 routes

• 11-cis-retinolReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by PCK1, PCK2, CS, DGAT1 and 4 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by PKM, PKLR, AGXT2, ABATmitochondrial matrixOne of 3 routes

• L-citrullineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-valineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-valine(out) + L-aspartate(in) = L-valine(in) + L-aspartate(out)

  Catalysed by PCK1, PCK2, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 11 routes

• L-arginineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• CHEBI:16497Reach from here →
  1. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by ENO4, ENO1, ENO2, ENO3 and 2 morecytosol

• protein polypeptide chainReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. PROTEIN_BS

  Catalysed by PCK1, PCK2, GOT2mitochondrial matrix, cytosolOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by PKM, PKLR, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 morecytosol

• (R)-glycerateReach from here →
  1. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  2. D-phosphoglycerate 2,3-phosphomutase
  3. (R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)

  Catalysed by ENO4, ENO1, ENO2, ENO3 and 5 morecytosolOne of 5 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 more

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by PKM, PKLR, LDHA, LDHB and 4 more

• CHEBI:16857Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• glyoxylic acidReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. D-aspartate:2-oxoglutarate aminotransferase
  3. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

  Catalysed by PCK1, PCK2, GOT2, HOGA1mitochondrial matrix

• ferrocytochrome cReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by PKM, PKLR, LDHB, LDHAL6B and 1 moremitochondrial matrix, cytosolOne of 2 routes

• N-acetyl-L-aspartateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by PCK1, PCK2, GOT2, NAT8Lmitochondrial matrixOne of 2 routes

• glycolaldehydeReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by PKM, PKLR, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by PKM, PKLR, NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. Aspartate Intake by System Asct-1 Transporter

  Catalysed by PCK1, PCK2, GOT2mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• itaconateReach from here →
  1. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
  2. citrate hydro-lyase (cis-aconitate-forming)
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A1, ACO2, ACOD1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol, endoplasmic reticulum

• anilineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PCK1, PCK2, CS, NAT2 and 1 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PCK1, PCK2, CSmitochondrial matrix, cytosolOne of 2 routes

• sulfiteReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by PCK1, PCK2, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by PCK1, PCK2, SDHB, SDHAmitochondrial matrix, cytosol

• AH2Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PKM, PKLR, AGXT2, MOCOSmitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PCK1, PCK2, CS, NAGSmitochondrial matrixOne of 22 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PCK1, PCK2, CS, HADHA and 2 moremitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by PKM, PKLR, AGXT2, AARS1mitochondrial matrix, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 6 moreextracellular space, cytosol

• urateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by PKM, PKLR, LDHB, LDHAL6B and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:17895Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• all-trans-retinalReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by PKM, PKLR, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

• CHEBI:17927Reach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PCK1, PCK2, CSmitochondrial matrix, cytosol

• 3-phenylpyruvateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by PKM, PKLR, KYAT1cytosol

• fumaric acidReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by PCK1, PCK2, FHmitochondrial matrix, cytosolOne of 6 routes

• CHEBI:18019Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by PKM, PKLR, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• thiocyanateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by PKM, PKLR, MPST, TSTcytosol

• 4-fumarylacetoacetateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by PKM, PKLR, FAHmitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)

  Catalysed by PCK1, PCK2, GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 19 routes

• dTTPReach from here →
  1. (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
  2. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
  3. pyruvate kinase (dTDP)

  Catalysed by ENO4, ENO1, ENO2, ENO3 and 2 morecytosolOne of 11 routes

• CHEBI:18095Reach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by PKM, PKLR, AGXT2, SLC1A4mitochondrial matrix, extracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by PKM, PKLR, TYW1B, TYW1 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by PKM, PKLR, AGXT2, BCKDHA and 1 moremitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by PKM, PKLR, AGXT2, SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by PKM, PKLR, SRR, SLC7A10inner side of the membrane, outer side of the membrane