D-ornithine

Three steps

• N-dodecanoylglycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-decanoylglycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-octanoylglycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-octanoyl-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• N-decanoyl-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• N-dodecanoyl-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• N-tetradecanoyl-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by DAO, AGXT2, PAMperoxisome

• L-homocarnosineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC25A2, SLC7A5, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GARTinner side of the membrane, outer side of the membrane, cytosol

• L-cystine-bis-glycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC25A2, GATM, DPEP1, DPEP2inner side of the membrane, outer side of the membrane, cytosol

• glycyldehydrophenylalanineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC25A2, GATM, DPEP1inner side of the membrane, outer side of the membrane, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC25A2, SLC7A6, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• kinetensinReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by SLC25A2, SLC7A6, CMA1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL2inner side of the membrane, outer side of the membrane, cytosol

• acetaldehydeReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• acetylpyruvateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by DAO, AGXT2, FAHD1peroxisome

• all-trans-retinoic acidReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by DAO, AGXT2, SLC16A4, SLC16A5 and 4 moreperoxisome, extracellular space, cytosolOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 5 routes

• (S)-malateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by DAO, AGXT2, ME2peroxisomeOne of 3 routes

• CHEBI:15611Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC25A2, GATM, GNMTinner side of the membrane, outer side of the membrane, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC25A2, SLC7A6, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, DHPSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, CARNS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC25A2, SLC7A6, THinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC25A2, SLC7A6, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ureaReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine amidinohydrolase

  Catalysed by SLC25A2, GATM, ARG1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by DAO, AGXT2peroxisome, mitochondrial matrix

• L-cystineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

  Catalysed by SLC25A2, GATM, SLC7A9inner side of the membrane, outer side of the membrane, cytosolOne of 7 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC25A2, SLC7A6, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by DAO, AGXT2, PCperoxisome, mitochondrial matrixOne of 3 routes

• nitric oxideReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC25A2, GATM, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC25A2, GATM, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. PROTEIN_BS

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC25A2, SLC7A6, EPXinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC25A2, SLC7A6, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC25A2, SLC7A6, MARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (S)-lactateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by DAO, AGXT2, LDHA, LDHB and 3 moreperoxisome

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by DAO, AGXT2, AADATperoxisomeOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC25A2, SLC7A6, CNDP2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by DAO, AGXT2peroxisomeOne of 3 routes

• tryptamineReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC25A2, SLC7A6, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by DAO, AGXT2, KYAT1peroxisome, cytosolOne of 5 routes

• 3-fumarylpyruvateReach from here →
  1. D-Ornithine:oxygen oxidoreductase (deaminating)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by DAO, AGXT2, FAHD1peroxisome

• CHEBI:16856Reach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, GATM, DAOinner side of the membrane, outer side of the membrane, cytosol, peroxisome