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Proteins/UNIPROT:Q13126
Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates..
Function from UniProtKB (Q13126), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
53 statements
53 statements · 5 reference databases · Subject: MTAP · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
S-methyl-5'-thioadenosine+phosphate(3-)adenine+5-(methylsulfanyl)-alpha-D-ribose 1-phosphate
Catalysed by MTAP
Reaction pageLeft to rightBalancedEC 2.4.2.28cytosol
Human-GEM MAR05384CC BY 4.0Reference data
S-methyl-5'-thioadenosine+hydrogenphosphate5-(methylsulfanyl)-alpha-D-ribose 1-phosphate+adenine
4 names
Resolves to: MTAP
Rhea RHEA:11852CC BY 4.0Reference data