spermine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

140 compounds within 3 steps: 3 in 1, 14 in 2, 123 in 3

One step

spermidineReach from here →
1. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
Catalysed by SMOX
N(1)-acetylspermineReach from here →
1. spermine + acetyl-CoA = N(1)-acetylspermine + CoA + H(+)
Catalysed by SAT1
3-aminopropanalReach from here →
1. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
Catalysed by SMOX

Two steps

CHEBI:1146900Reach from here →
1. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
2. diamine N-acetyltransferase (N1-acetylspermidine)
Catalysed by SMOX, SAT1, SAT2cytosolOne of 3 routes
trimethylenediamineReach from here →
1. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
2. deoxyhypusine synthase (1,3-diaminopropane)
Catalysed by SMOX, DHPScytosolOne of 2 routes
CHEBI:15746Reach from here →

Three steps

Catalysed by SMOX, SRM, SMScytosol

S-methyl-5'-thioadenosineReach from here →

Catalysed by SMOX, SRM, SMScytosolOne of 2 routes

CHEBI:17769Reach from here →

Catalysed by SMOXcytosol

CHEBI:17927Reach from here →

Catalysed by SMOX, SAT1, SAT2cytosolOne of 2 routes

N-(4-aminobutyl)-3-aminopropanalReach from here →

Catalysed by SMOX, AOC2, AOC1, AOC3cytosolOne of 3 routes

3-acetamidopropanalReach from here →

Catalysed by SAT1, PAOX

putrescineReach from here →

Catalysed by SMOX, SRM

S-adenosyl 3-(methylsulfanyl)propylamineReach from here →

Catalysed by SMOX, SRM

propane-1,3-diamineReach from here →

Catalysed by SMOX, DHPS

beta-alanineReach from here →

Catalysed by SMOX, ALDH2, ALDH1B1mitochondrial matrixOne of 3 routes

N(1)-acetylspermidineReach from here →

Catalysed by SMOX, SAT1

N(8)-acetylspermidineReach from here →

Catalysed by SMOXcytosolOne of 3 routes

Catalysed by SMOX, SAT1, SAT2, CPT1A and 2 more

cytosol

One of 3 routes

CHEBI:15345Reach from here →

Catalysed by SMOX, SAT1, SAT2, AACScytosolOne of 2 routes

cholineReach from here →

Catalysed by SMOX, SAT1, SAT2, CHATcytosol, nucleus

CHEBI:15380Reach from here →

Catalysed by SMOX, SAT1, SAT2, ALAS1 and 1 morecytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by SMOX, SAT1, SAT2, GLYAT and 2 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, CPT1A and 1 morecytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, GLYATcytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, GLYAT and 2 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by SMOX, SAT1, SAT2, ACAA1 and 2 morecytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 11 routes

oleoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, CPT1A and 2 morecytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2cytosolOne of 3 routes

propionyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, ACSS3 and 2 morecytosolOne of 43 routes

CHEBI:15650Reach from here →

Catalysed by SMOX, SAT1, SAT2, ZDHHC11B and 31 morecytosolOne of 2 routes

CHEBI:15727Reach from here →

Catalysed by SMOX, SAT1, SAT2, NAA10cytosolOne of 2 routes

11-cis-retinolReach from here →

Catalysed by SMOX, SAT1, SAT2, DGAT1 and 4 morecytosol

oxaloacetateReach from here →

Catalysed by SMOX, SAT1, SAT2, ACLYcytosol

L-arginineReach from here →

Catalysed by SMOX, SAT1, SAT2, SLC3A2 and 1 morecytosol, extracellular spaceOne of 2 routes

adenineReach from here →

Catalysed by SMOX, SRM, SMS, MTAPcytosolOne of 2 routes

anilineReach from here →

Catalysed by SMOX, SAT1, SAT2, NAT2 and 1 morecytosol

CHEBI:17312Reach from here →

Catalysed by SMOX, SRM, SMS, SAT1 and 1 morecytosolOne of 4 routes

L-cysteineReach from here →

Catalysed by SMOX, SAT1, SAT2, NAGScytosol, mitochondrial matrix

(7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrix

3-oxopropanoic acidReach from here →

Catalysed by SMOX, ALDH2, ALDH1B1, ABATmitochondrial matrix

CHEBI:18019Reach from here →

Catalysed by SMOX, DHPScytosol

spermine monoaldehydeReach from here →

Catalysed by SMOX, SRM, SMS, AOC2 and 2 morecytosolOne of 3 routes

(5Z)-dodecenoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

(11Z)-docosenoyl-CoA(4-)Reach from here →

Catalysed by SMOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 5 routes

(7Z)-tetradecenoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, SLC27A2 and 7 morecytosolOne of 8 routes

(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →

Catalysed by SMOX, SAT1, SAT2, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes