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2'-deoxyadenosine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

19 compounds within 3 steps: 2 in 1, 5 in 2, 12 in 3

Does it reach a compound?

One step

adenineReach from here →
1. Deoxyadenosine:orthophosphate ribosyltransferase
Catalysed by PNPcytosol
2'-deoxyinosineReach from here →
1. deoxyadenosine aminohydrolase
Catalysed by ADA, ADA2cytosolOne of 3 routes

Two steps

adenosineReach from here →
1. Deoxyadenosine:orthophosphate ribosyltransferase
2. adenosine:phosphate alpha-D-ribosyltransferase
Catalysed by PNPcytosol
hypoxanthineReach from here →
1. deoxyadenosine aminohydrolase
2. Deoxyinosine:orthophosphate ribosyltransferase
Catalysed by ADA, ADA2, PNPcytosolOne of 3 routes
inosineReach from here →

Three steps

uridineReach from here →
Catalysed by ADA, ADA2, NT5C2cytosol
guanosineReach from here →
Catalysed by ADA, ADA2, NT5C2

deoxyadenosine aminohydrolase

dIMP + inosine = 2'-deoxyinosine + IMP

Catalysed by ADA, ADA2, NT5C2cytosol

2-deoxy-alpha-D-ribose 1-phosphateReach from here →

deoxyadenosine aminohydrolase
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

Catalysed by ADA, ADA2, PNPcytosol

dIMPReach from here →

deoxyadenosine aminohydrolase
dIMP + inosine = 2'-deoxyinosine + IMP

Catalysed by ADA, ADA2, NT5C2cytosol

cytosol

2'-deoxyguanosineReach from here →

deoxyadenosine aminohydrolase
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Catalysed by ADA, ADA2, PNPcytosolOne of 2 routes

CHEBI:17202Reach from here →

deoxyadenosine aminohydrolase
Deoxyinosine:orthophosphate ribosyltransferase
IMP:diphosphate phospho-D-ribosyltransferase

Catalysed by ADA, ADA2, PNP, HPRT1cytosolOne of 3 routes

cytidineReach from here →

deoxyadenosine aminohydrolase
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + CMP = cytidine + IMP

Catalysed by ADA, ADA2, NT5C2cytosol

xanthineReach from here →

deoxyadenosine aminohydrolase
Deoxyinosine:orthophosphate ribosyltransferase
hypoxanthine:NAD+ oxidoreductase

Catalysed by ADA, ADA2, PNP, XDHcytosolOne of 4 routes

CHEBI:28862Reach from here →

Deoxyadenosine:orthophosphate ribosyltransferase
adenosine:phosphate alpha-D-ribosyltransferase
Adenosine Kinase

Catalysed by PNPcytosol

D-ribose 1-phosphateReach from here →

deoxyadenosine aminohydrolase
dIMP + inosine = 2'-deoxyinosine + IMP
inosine:phosphate alpha-D-ribosyltransferase

Catalysed by ADA, ADA2, NT5C2, PNPcytosolOne of 2 routes

alpha-D-ribose 1-phosphateReach from here →

deoxyadenosine aminohydrolase
dIMP + inosine = 2'-deoxyinosine + IMP
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine

Catalysed by ADA, ADA2, NT5C2, PNP and 1 morecytosolOne of 2 routes

IMPReach from here →

deoxyadenosine aminohydrolase
Deoxyinosine:orthophosphate ribosyltransferase
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Catalysed by ADA, ADA2, PNP, HPRT1cytosolOne of 8 routes

(2R)-3-phosphoglycerateReach from here →

deoxyadenosine aminohydrolase
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

Catalysed by ADA, ADA2, PNP, PGM2L1cytosol

2-deoxy-D-ribose 5-phosphateReach from here →

deoxyadenosine aminohydrolase
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

Catalysed by ADA, ADA2, PNP, PGM2cytosol