2-oxoglutaramate

Three steps

• D-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-aminolevulinateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by KYAT1, SLC7A5, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by KYAT1, SLC7A5, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by KYAT1, AADATOne of 4 routes

• glycochenodeoxycholateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by KYAT1, SLC7A5, BAATextracellular space, cytosol

• glycochenodeoxycholic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by KYAT1, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glycolithocholic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by KYAT1, SLC7A5, BAATextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by KYAT1, SLC7A5, GCATextracellular space, cytosol, mitochondrial matrix

• D-glucopyranose 6-phosphateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
  3. glucose-6-phosphatase (carbamoyl-phosphate)

  Catalysed by KYAT1, CAD, G6PC2cytosol, endoplasmic reticulum

• gamma-Glu-AlaReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by KYAT1, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by KYAT1, SLC7A5, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by KYAT1, SLC6A14, SLC6A6extracellular space, cytosolOne of 4 routes

• (R)-methylmalonyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by KYAT1, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by KYAT1cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by KYAT1, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by KYAT1cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by KYAT1, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by KYAT1, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by KYAT1, CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by KYAT1, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by KYAT1, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. phytanate-CoA ligase

  Catalysed by KYAT1cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 4 morecytosolOne of 15 routes

• D-alanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by KYAT1, SLC7A5, PIPOXextracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by KYAT1, SLC7A5, SHMT1, SHMT2extracellular space, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by KYAT1, SLC7A6, ASLextracellular space, cytosolOne of 6 routes

• 4-guanidinobutanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by KYAT1, SLC7A6, GATMextracellular space, cytosol

• 2-oxoadipateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by KYAT1, AADAT

• L-dopaReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by KYAT1, GOT2, TAT, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase

  Catalysed by KYAT1, GFPT2, GFPT1, GNPNAT1cytosolOne of 3 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by KYAT1, SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by KYAT1, SLC7A6, GATMextracellular space, cytosol

• L-histidineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by KYAT1, GOT2, TAT, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 7 routes

• beta-D-fructose 6-phosphateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

  Catalysed by KYAT1, GFPT2, GFPT1, GNPDA1 and 1 morecytosol

• D-ornithineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by KYAT1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by KYAT1, SLC7A5, GLYATL3, GLYAT and 1 moreextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 2 moreextracellular space, cytosolOne of 3 routes

• guanidinoacetateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by KYAT1, SLC7A5, GATMextracellular space, cytosolOne of 5 routes

• sphing-4-enineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by KYAT1, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatusOne of 2 routes

• D-threonineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• spermidineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by KYAT1, SAT1, SAT2cytosolOne of 3 routes

• L-dopaquinoneReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by KYAT1, SLC7A5, TYRextracellular space, cytosol

• glutathioneReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by KYAT1, SLC7A5, GSSextracellular space, cytosol

• L-saccharopineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by KYAT1, SLC7A6, AASSextracellular space, cytosol, mitochondrial matrix