N-[(S)-lactoyl]-L-phenylalanine

Three steps

• 2-phenylacetaldehydeReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by CNDP2, DDC, AOC2, AOC1 and 3 morecytosolOne of 2 routes

• oxaloacetateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 moremitochondrial matrixOne of 8 routes

• nitric oxideReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by CNDP2, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CNDP2, SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by CNDP2, SLC7A6, ACY1extracellular space, cytosol

• anthranilateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by CNDP2, SLC7A8, KYNUextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CNDP2, SLC7A5, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CNDP2, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CNDP2, SLC7A5, AADATextracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 moreOne of 2 routes

• tryptamineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by CNDP2, SLC7A5, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 morecytosolOne of 6 routes

• enol-phenylpyruvateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by CNDP2, GOT2, TAT, MIFmitochondrial matrix

• 3-fumarylpyruvateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• CHEBI:16856Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin E3(out) + 2 (S)-lactate(in) = prostaglandin E3(in) + 2 (S)-lactate(out)
  3. transport of GSH and prostaglandin E3 (cytosol to extracellular)

  Catalysed by CNDP2, SLCO2A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 16 routes

• glyoxylic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by CNDP2, SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by CNDP2, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by CNDP2, SLC6A14, SLC26A6extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 8 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• CHEBI:17208Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by CNDP2, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by CNDP2, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• aceneuramateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• 5'-deoxyadenosineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 4 more

• CHEBI:17380Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by CNDP2, SLC7A5extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by CNDP2, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by CNDP2, SLC7A6extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CNDP2, SLC7A5, MOCOSextracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by CNDP2, SLC7A5, ALAS1, ALAS2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by CNDP2, SLC7A5, IL4I1extracellular space, cytosolOne of 2 routes

• xanthineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by CNDP2, SLC22A12, SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by CNDP2, SLC7A5, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by CNDP2, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by CNDP2, SLC7A6, HALextracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by CNDP2, SLC7A5, TPH1, TPH2extracellular space, cytosol

• prostaglandin F1Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin E1(out) + 2 (S)-lactate(in) = prostaglandin E1(in) + 2 (S)-lactate(out)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by CNDP2, SLCO2A1, DHRS1inner side of the membrane, outer side of the membrane

• 4-methyl-2-oxopentanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by CNDP2, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by CNDP2, SLC7A6, SLC3A2extracellular space, cytosol

• 5-hydroxyisourateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. urate:oxygen oxidoreductase

  Catalysed by CNDP2, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• dTDPReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. pyruvate kinase (dTDP)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 4 morecytosol

• CHEBI:18095Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by CNDP2, SLC7A5, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Transport of 3-Ureidopropionate

  Catalysed by CNDP2, SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by CNDP2, SLC7A5, GARTextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by CNDP2, SLC7A5, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by CNDP2, SLC7A5, GSSextracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by CNDP2, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by CNDP2, SLC7A5, AGXT2extracellular space, cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more