L-arginine

Two steps

• malonic acidReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Malonate Transport, Antiport with Chloride

  Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

• D-lysineReach from here →
  1. L-Arginine amidinohydrolase
  2. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by ARG1, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-arginineReach from here →
  1. L-Arginine amidinohydrolase
  2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by ARG1, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A6, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. De novo synthesis of 2Fe2S

  Catalysed by SLC7A6, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of arginine and isoleucine (cytosol to extracellular)
  2. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A6, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC7A6, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of arginine and isoleucine (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A6, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of arginine and tyrosine (cytosol to extracellular)
  2. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A6, GOT2, GOT1, TATextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC7A6, BAATextracellular space, cytosol

• glycochenodeoxycholic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC7A6, AADATextracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC7A6, BAATextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC7A6, GCATextracellular space, cytosol, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLC7A6, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC7A6, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC6A14, SLC6A6extracellular space, cytosolOne of 3 routes

• D-alanineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC7A6, PIPOXextracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC7A6, SHMT1, SHMT2extracellular space, cytosol

• carnosineReach from here →
  1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
  2. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLC7A6, CARNS1inner side of the membrane, outer side of the membrane

• L-dopaReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by SLC7A6, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-ornithineReach from here →
  1. L-Arginine amidinohydrolase
  2. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by ARG1, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL3, GLYAT, GLYATL2extracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A6, GOT2, GOT1extracellular space, cytosolOne of 3 routes

• D-threonineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• spermidineReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by SLC3A2, SLC7A7, SRMextracellular space, cytosolOne of 4 routes

• L-dopaquinoneReach from here →
  1. transport of arginine and tyrosine (cytosol to extracellular)
  2. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by SLC7A6, TYRextracellular space, cytosol

• glutathioneReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by SLC7A6, GSSextracellular space, cytosol

• L-threonineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

• L-saccharopineReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, AASSextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• L-kynurenineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC7A6, KYNUextracellular space, cytosolOne of 5 routes

• beta-alanineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• leukotriene C4Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. leukotriene C4 hydrolysis

  Catalysed by SLC7A6extracellular space, cytosol

• dimethylamineReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
  2. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by SLC25A2, DDAH1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-glutamate 5-semialdehydeReach from here →
  1. L-Arginine amidinohydrolase
  2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by ARG1, OATcytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SLC7A6, KYNUextracellular space, cytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. transport of arginine and cysteine (cytosol to extracellular)
  2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SLC7A6, GCLC, GCLMextracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by SLC3A2, SLC7A5, SLC7A6extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A6, BHMT2extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  2. Carbamoyl-phosphate:L-ornithine carbamoyltransferase

  Catalysed by NOS3, NOS1, NOS2, OTCcytosol, mitochondrial matrixOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A6, BHMT2extracellular space, cytosol

• N-acetylputrescineReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. acetyl-CoA:putrescine N-acetyltransferase

  Catalysed by SLC3A2, SLC7A7, SAT1, SAT2extracellular space, cytosolOne of 2 routes

• 4-aminobutanalReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

  Catalysed by SLC3A2, SLC7A7, AOC1extracellular space, cytosol

• glutathione disulfideReach from here →
  1. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
  2. cystine to cysteine conversion

  Catalysed by SLC7A9inner side of the membrane, outer side of the membrane, cytosol

• L-tyrosineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC7A6, AADATextracellular space, cytosolOne of 2 routes

• N(1)-acetylspermidineReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

  Catalysed by SLC3A2, SLC7A7, PAOXextracellular space, cytosol

• trans-4-hydroxy-L-prolineReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC7A6, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes