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Proteins/UNIPROT:P05362
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1..
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins..
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins..
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell..
Function from UniProtKB (P05362), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
433 statements
433 statements · 4 reference databases · Subject: ICAM1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
3 names
Resolves to: ICAM1