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Proteins/UNIPROT:P08183
Translocates phospholipids and drugs across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates..
Function from UniProtKB (P08183), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
155 statements
155 statements · 8 reference databases · Subject: ABCB1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
59 reactions
ATP+MAM01695c+waterADP+MAM01695e+proton+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11648CC BY 4.0Reference data
7 names
Resolves to: ABCB1
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11695CC BY 4.0Reference data
ATP+water+MAM03936cADP+proton+phosphate(3-)+MAM03936e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11696CC BY 4.0Reference data
ATP+water+MAM03937cADP+proton+phosphate(3-)+MAM03937e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11698CC BY 4.0Reference data
ATP+water+MAM03938cADP+proton+phosphate(3-)+MAM03938e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11700CC BY 4.0Reference data
ATP+water+MAM03940cADP+proton+phosphate(3-)+MAM03940e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11702CC BY 4.0Reference data
ATP+water+MAM03939cADP+proton+phosphate(3-)+MAM03939e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11704CC BY 4.0Reference data
ATP+water+MAM03941cADP+proton+phosphate(3-)+MAM03941e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11706CC BY 4.0Reference data
ATP+water+MAM03943cADP+proton+phosphate(3-)+MAM03943e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11708CC BY 4.0Reference data
ATP+water+MAM03942cADP+proton+phosphate(3-)+MAM03942e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11710CC BY 4.0Reference data
ATP+water+MAM03945cADP+proton+phosphate(3-)+MAM03945e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11712CC BY 4.0Reference data
ATP+water+MAM03944cADP+proton+phosphate(3-)+MAM03944e
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11714CC BY 4.0Reference data