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Proteins/UNIPROT:Q8TCT0
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides..
Function from UniProtKB (Q8TCT0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
209 statements
209 statements · 7 reference databases · Subject: CERK · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
ATP+an N-acylsphing-4-enineADP+MAM01431c+proton
Catalysed by CERK
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.138cytosol
Human-GEM MAR00760CC BY 4.0Reference data
an N-acylsphing-4-enine+ATP(4-)an N-acylsphing-4-enine 1-phosphate+ADP(3-)+hydron
Catalysed by AGK or
5 names
Resolves to: CERK
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17929CC BY 4.0Reference data
N-(hexanoyl)sphing-4-enine+ATP(4-)N-hexanoylsphing-4-enine 1-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43312CC BY 4.0Reference data
N-hexadecanoylsphing-4-enine+ATP(4-)N-(hexadecanoyl)-sphing-4-enine-1-phosphate+ADP(3-)+hydron
Catalysed by CERK
Reaction pageLeft to rightBalanced
Rhea RHEA:46340CC BY 4.0Reference data
N-(acetyl)-sphing-4-enine+ATP(4-)N-(acetyl)-sphing-4-enine-1-phosphate+ADP(3-)+hydron
Catalysed by CERK
Reaction pageLeft to rightBalanced
Rhea RHEA:47904CC BY 4.0Reference data
CHEBI:88095+ATP(4-)CHEBI:88096+ADP(3-)+hydron
Catalysed by CERK
Reaction pageLeft to rightBalanced
Rhea RHEA:47916CC BY 4.0Reference data