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Proteins/UNIPROT:Q96G23
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity). Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity)..
Function from UniProtKB (Q96G23), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
202 statements
202 statements · 7 reference databases · Subject: CERS2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
23 reactions
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
7 names
Resolves to: CERS2
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00758CC BY 4.0Reference data
sphing-4-enine+a fatty acyl-CoAan N-acylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23768CC BY 4.0Reference data
hexacosanoyl-CoA+sphinganineN-hexacosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33351CC BY 4.0Reference data
tetracosanoyl-CoA+sphinganineN-tetracosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33591CC BY 4.0Reference data
docosanoyl-CoA+sphinganineN-docosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36535CC BY 4.0Reference data
sphinganine+hexadecanoyl-CoAN-hexadecanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS6 or CERS5 or CERS2
Reaction pageLeft to rightBalanced
Rhea RHEA:36539CC BY 4.0Reference data
sphinganine+octadecanoyl-CoAN-(octadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36547CC BY 4.0Reference data
eicosanoyl-CoA+sphinganineN-eicosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36555CC BY 4.0Reference data
sphinganine+(9Z)-octadecenoyl-CoAN-(9Z-octadecenoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36575CC BY 4.0Reference data
2-hydroxydocosanoyl-CoA+sphinganineN-(2-hydroxydocosanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36619CC BY 4.0Reference data
2-hydroxytetracosanoyl-CoA+sphinganineN-(2-hydroxytetracosanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36627CC BY 4.0Reference data