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Proteins/UNIPROT:Q92851
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC..
Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis..
Isoform C is proteolytically inactive..
Function from UniProtKB (Q92851), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
355 statements
355 statements · 4 reference databases · Subject: CASP10 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
7 names
Resolves to: CASP10