HS-GAG degradation

Lysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation. The steps outlined below describe the cleavage of heparan sulfate/heparin from heparan sulfate proteoglycans (HSPGs) and its degradation. Complete degradation of glycoproteins is required to avoid build up of glycosaminoglycan fragments which can cause lysosomal storage diseases. The proteolysis of the core protein of the glycoprotein is not shown here.

Summary from Reactome (R-HSA-2024096), read 2026-09-23.