Proteins/UNIPROT:P53634

CTSC

ProteinUNIPROT:P53634

Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B..

Function from UniProtKB (P53634), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

ectodermal dysplasia syndrome has a germline basis in CTSCDiseaseGenCC HGNC:2528|MONDO:0019287Inferred only
Haim-Munk syndrome has a germline basis in CTSCDiseaseGenCC HGNC:2528|MONDO:0009491Inferred only
Papillon-Lefevre disease has a germline basis in CTSCDiseaseGenCC HGNC:2528|MONDO:0009490Inferred only

Statements

26 statements

26 statements · 5 reference databases · Subject: CTSC · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

CAPN1 interacts with CTSCProteinHetionet hetionet:interacts:1075-823Inferred only
CTSC interacts with CTSLProteinHetionet hetionet:interacts:1075-1514Inferred only
CTSC participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
CTSC participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
CTSC participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
CTSC participates in Cargo concentration in the ERPathwayReactome R-HSA-5694530Inferred only
CTSC participates in COPII-mediated vesicle transportPathwayReactome R-HSA-204005Inferred only
CTSC participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
CTSC participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CTSC participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
CTSC participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CTSC participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only

Show the remaining 14

CTSC participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CTSC participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
CTSC participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
CTSC participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
CTSC participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
CTSC participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CTSC participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
CTSC participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
CTSC participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
CTSC participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
CTSC regulates positive regulation of protein catabolic processBiological processgene ontology P53634|GO:0045732Inferred only
EIF2B2 decreases the expression of CTSCProteinHetionet hetionet:regulates:8892-1075Inferred only
MTOR decreases the expression of CTSCProteinHetionet hetionet:regulates:2475-1075Inferred only
CTSC requires the cofactor chlorideCompoundUniProt P53634Inferred only

Reactions

15 reactions

MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971

Other names

11 names

Resolves to: CTSC

Also called: ; Dipeptidyl peptidase 1 light chainCathepsin CCathepsin JCPPIDipeptidyl peptidase IDipeptidyl peptidase I exclusion domain chainDipeptidyl peptidase I heavy chainDipeptidyl peptidase I light chainDipeptidyl transferaseDPP-IDPPI

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+9L-isoleucine

+64L-leucine

+60CHEBI:18019

+7L-methionine

+35L-phenylalanine

+608phosphate(3-)

+24CHEBI:17203

+28L-seryl residue

+29CHEBI:16857

+2L-tryptophan

+19CHEBI:17895

+43L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05259CC BY 4.0Reference data

MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05261CC BY 4.0Reference data

MAM01345l+417ATP+834water417ADP+26L-alanine+7L-arginine+19L-asparagine+24L-aspartate+3L-cysteine+32L-glutamate(1-)+18L-glutamine+24glycine+432proton+13CHEBI:15971+20L-isoleucine+51L-leucine+34CHEBI:18019+10L-methionine+27L-phenylalanine+417phosphate(3-)+19CHEBI:17203+25L-seryl residue+30CHEBI:16857+3L-tryptophan+6CHEBI:17895+27L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05263CC BY 4.0Reference data

MAM01351l+4560ATP+9120water4560ADP+275L-alanine+150L-arginine+247L-asparagine+233L-aspartate+25L-cysteine+298L-glutamate(1-)+230L-glutamine+207glycine+4584proton+115CHEBI:15971+285L-isoleucine+533L-leucine+357CHEBI:18019+79L-methionine+224L-phenylalanine+4560phosphate(3-)+171CHEBI:17203+392L-seryl residue+300CHEBI:16857+37L-tryptophan+151CHEBI:17895+252L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05265CC BY 4.0Reference data

2673ATP+MAM01827l+5346water2673ADP+134L-alanine+134L-arginine+138L-asparagine+176L-aspartate+48L-cysteine+186L-glutamate(1-)+110L-glutamine+262glycine+2747proton+62CHEBI:15971+104L-isoleucine+166L-leucine+154CHEBI:18019+48L-methionine+98L-phenylalanine+2673phosphate(3-)+114CHEBI:17203+278L-seryl residue+182CHEBI:16857+60L-tryptophan+98CHEBI:17895+122L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05272CC BY 4.0Reference data

405ATP+810water+MAM02044l405ADP+30L-alanine+9L-arginine+21L-asparagine+25L-aspartate+12L-cysteine+25L-glutamate(1-)+17L-glutamine+31glycine+411proton+13CHEBI:15971+18L-isoleucine+31L-leucine+35CHEBI:18019+5L-methionine+8L-phenylalanine+405phosphate(3-)+21CHEBI:17203+18L-seryl residue+22CHEBI:16857+8L-tryptophan+21CHEBI:17895+36L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05274CC BY 4.0Reference data

809ATP+1618water+MAM02753l809ADP+37L-alanine+42L-arginine+40L-asparagine+36L-aspartate+48L-cysteine+56L-glutamate(1-)+31L-glutamine+62glycine+810proton+24CHEBI:15971+22L-isoleucine+48L-leucine+49CHEBI:18019+11L-methionine+21L-phenylalanine+809phosphate(3-)+69CHEBI:17203+56L-seryl residue+61CHEBI:16857+19L-tryptophan+30CHEBI:17895+48L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05276CC BY 4.0Reference data

621ATP+1242water+MAM02802l621ADP+42L-alanine+44L-arginine+25L-asparagine+35L-aspartate+26L-cysteine+51L-glutamate(1-)+26L-glutamine+49glycine+634proton+13CHEBI:15971+22L-isoleucine+51L-leucine+29CHEBI:18019+9L-methionine+21L-phenylalanine+621phosphate(3-)+33CHEBI:17203+38L-seryl residue+36CHEBI:16857+14L-tryptophan+21CHEBI:17895+37L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05278CC BY 4.0Reference data

MAM00186l+697ATP+1394water697ADP+61L-alanine+27L-arginine+34L-asparagine+45L-aspartate+40L-cysteine+42L-glutamate(1-)+17L-glutamine+52glycine+699proton+19CHEBI:15971+15L-isoleucine+65L-leucine+58CHEBI:18019+10L-methionine+28L-phenylalanine+697phosphate(3-)+32CHEBI:17203+41L-seryl residue+30CHEBI:16857+8L-tryptophan+26CHEBI:17895+48L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05280CC BY 4.0Reference data

MAM01359l+316ATP+632water316ADP+39L-alanine+34L-arginine+L-asparagine+11L-aspartate+2L-cysteine+40L-glutamate(1-)+32L-glutamine+18glycine+320proton+2CHEBI:15971+2L-isoleucine+41L-leucine+13CHEBI:18019+8L-methionine+4L-phenylalanine+316phosphate(3-)+8CHEBI:17203+14L-seryl residue+12CHEBI:16857+8L-tryptophan+4CHEBI:17895+24L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05282CC BY 4.0Reference data

MAM01350l+266ATP+532water266ADP+23L-alanine+17L-arginine+5L-asparagine+16L-aspartate+30L-glutamate(1-)+19L-glutamine+11glycine+273proton+6CHEBI:15971+41L-leucine+22CHEBI:18019+4L-methionine+8L-phenylalanine+266phosphate(3-)+10CHEBI:17203+16L-seryl residue+12CHEBI:16857+5L-tryptophan+7CHEBI:17895+15L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05284CC BY 4.0Reference data

284ATP+568water+MAM02935l284ADP+21L-alanine+20L-arginine+11L-asparagine+10L-aspartate+5L-cysteine+22L-glutamate(1-)+17L-glutamine+21glycine+277proton+6CHEBI:15971+10L-isoleucine+31L-leucine+19CHEBI:18019+12L-methionine+6L-phenylalanine+284phosphate(3-)+12CHEBI:17203+20L-seryl residue+12CHEBI:16857+5L-tryptophan+4CHEBI:17895+21L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05285CC BY 4.0Reference data

Show the remaining 3