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Proteins/UNIPROT:P27144
Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress..
Function from UniProtKB (P27144), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
102 statements
102 statements · 8 reference databases · Subject: AK4 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
23 reactions
4 names
Resolves to: AK4
Reaction pageReversibleBalancedEC 2.7.4.3mitochondrial matrix
Human-GEM MAR04004CC BY 4.0Reference data
ADP+CHEBI:16174ATP+MAM01639c
Catalysed by AK2 or AK6 or AK1 or AK7 or AK3 or AK5 or AK9 or AK4 or AK8 or ACAD9
Reaction pageReversibleBalancedEC 2.7.4.11, 2.7.4.3cytosol
Human-GEM MAR04480CC BY 4.0Reference data
Catalysed by AK4 or CMPK1 or CMPK2 or AK9
Reaction pageDirection not assertedBalanced
Rhea RHEA:11600CC BY 4.0Reference data
Catalysed by AK1 or AK4 or AK2 or AK9 or AK7 or AK8 or AK6 or AK5
Reaction pageDirection not assertedBalanced
Rhea RHEA:12973CC BY 4.0Reference data
a ribonucleoside 5'-diphosphate+ATP(4-)a ribonucleoside 5'-triphosphate+ADP(3-)
Catalysed by NME4 or NME6 or AK1 or NME1 or NME2 or AK4 or CMPK1 or NME3 or CMPK2 or AK9 or AK7 or AK8 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18113CC BY 4.0Reference data
CHEBI:58245+ATP(4-)dADP+ADP(3-)
Catalysed by AK1 or AK4 or AK9
Reaction pageDirection not assertedBalanced
Rhea RHEA:23100CC BY 4.0Reference data
CHEBI:58043+ATP(4-)a ribonucleoside 5'-diphosphate+ADP(3-)
Catalysed by AK1 or AK4 or AK9
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24036CC BY 4.0Reference data
Catalysed by AK4 or CMPK1 or CMPK2 or AK9
Reaction pageDirection not assertedBalanced
Rhea RHEA:25094CC BY 4.0Reference data
Catalysed by NME4 or NME6 or AK1 or NME1 or NME2 or AK4 or NME3 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:25098CC BY 4.0Reference data
Catalysed by NME4 or NME6 or NME1 or NME2 or AK4 or AK9
Reaction pageLeft to rightBalanced
Rhea RHEA:25237CC BY 4.0Reference data
Catalysed by NME4 or NME1 or AK4 or AK9
Reaction pageReversibleBalanced
Rhea RHEA:27678CC BY 4.0Reference data