Proteins/UNIPROT:Q13474

DRP2

ProteinUNIPROT:Q13474

Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system..

Function from UniProtKB (Q13474), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Charcot-Marie-Tooth disease has a germline basis in DRP2DiseaseGenCC HGNC:3032|MONDO:0015626Inferred only

Statements

17 statements

17 statements · 2 reference databases · Subject: DRP2 · Sources: Hetionet, Reactome

Order

ABCA2 covaries with DRP2ProteinHetionet hetionet:covaries:1821-20Inferred only
DRP2 covaries with DTX3ProteinHetionet hetionet:covaries:1821-196403Inferred only
DRP2 covaries with GPR173ProteinHetionet hetionet:covaries:1821-54328Inferred only
DRP2 covaries with NYAP1ProteinHetionet hetionet:covaries:1821-222950Inferred only
DRP2 covaries with TFE3ProteinHetionet hetionet:covaries:1821-7030Inferred only
DAG1 interacts with DRP2ProteinHetionet hetionet:interacts:1605-1821Inferred only
DRP2 interacts with DTNAProteinHetionet hetionet:interacts:1821-1837Inferred only
DRP2 interacts with PRXProteinHetionet hetionet:interacts:1821-57716Inferred only
DRP2 interacts with UTRNProteinHetionet hetionet:interacts:1821-7402Inferred only
DRP2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DRP2 participates in EGR2 and SOX10-mediated initiation of Schwann cell myelinationPathwayReactome R-HSA-9619665Inferred only
DRP2 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only

Show the remaining 5

DRP2 participates in Formation of the dystrophin-glycoprotein complex (DGC)PathwayReactome R-HSA-9913351Inferred only
DRP2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
DRP2 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
DRP2 decreases the expression of CTSLProteinHetionet hetionet:regulates:1821-1514Inferred only
DRP2 decreases the expression of GTF2E2ProteinHetionet hetionet:regulates:1821-2961Inferred only

Other names

2 names

Resolves to: DRP2

Also called: DRP-2Dystrophin-related protein 2

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