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Proteins/UNIPROT:Q9BV23
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting..
Function from UniProtKB (Q9BV23), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
309 statements
309 statements · 5 reference databases · Subject: ABHD6 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea · Rows fetched: 300
27 reactions
MAM01570eMAM01569e+77243a triacylglycerol
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00001CC BY 4.0Reference data
a monoacylglycerol+waterMAM01807c+MAM01983c
Catalysed by MGLL
2 names
Resolves to: ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00005CC BY 4.0Reference data
MAM03147e10385a triacylglycerol+MAM03146e
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00006CC BY 4.0Reference data
a monoacylglycerol+waterfatty acid+MAM01983c
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00010CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00679CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00680CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00681CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00682CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00683CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00684CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
a 1-acylglycerol+waterglycerol+a fatty acid+hydron
Catalysed by DDHD2 or MGLL or ABHD6 or ABHD16B
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:34019CC BY 4.0Reference data