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Proteins/UNIPROT:O75911
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. It limits excessive synthesis of all-trans retinoic acid (RA) from all-trans-retinal..
Function from UniProtKB (O75911), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
135 statements
135 statements · 8 reference databases · Subject: DHRS3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300cytosol
Human-GEM MAR06630CC BY 4.0Reference data
7 names
Resolves to: DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300endoplasmic reticulum
Human-GEM MAR06632CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data