Proteins/UNIPROT:P25774

CTSS

ProteinUNIPROT:P25774

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity)..

Function from UniProtKB (P25774), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

41 statements

41 statements · 3 reference databases · Subject: CTSS · Sources: gene ontology, Hetionet, Reactome

Order

ZNF581 covaries with CTSSProteinHetionet hetionet:covaries:1520-51545Inferred only
BGLAP interacts with CTSSProteinHetionet hetionet:interacts:1520-632Inferred only
CST3 interacts with CTSSProteinHetionet hetionet:interacts:1471-1520Inferred only
CST5 interacts with CTSSProteinHetionet hetionet:interacts:1473-1520Inferred only
CTSS interacts with IRF1ProteinHetionet hetionet:interacts:1520-3659Inferred only
CTSS interacts with IRF2ProteinHetionet hetionet:interacts:1520-3660Inferred only
CTSS interacts with KNG1ProteinHetionet hetionet:interacts:1520-3827Inferred only
CTSS interacts with PLCG1ProteinHetionet hetionet:interacts:1520-5335Inferred only
CTSS interacts with SERPINB3ProteinHetionet hetionet:interacts:1520-6317Inferred only
CTSS interacts with SERPINB4ProteinHetionet hetionet:interacts:1520-6318Inferred only
CTSS interacts with SLPIProteinHetionet hetionet:interacts:1520-6590Inferred only
CTSS participates in Activation of STAT3 by cadherin engagementPathwayReactome R-HSA-9958825Inferred only

Show the remaining 29

CTSS participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
CTSS participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
CTSS participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
CTSS participates in Antigen processing-Cross presentationPathwayReactome R-HSA-1236975Inferred only
CTSS participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
CTSS participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
CTSS participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
CTSS participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
CTSS participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
CTSS participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
CTSS participates in Degradation of CDH1PathwayReactome R-HSA-9766229Inferred only
CTSS participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
CTSS participates in Endosomal/Vacuolar pathwayPathwayReactome R-HSA-1236977Inferred only
CTSS participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
CTSS participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CTSS participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
CTSS participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CTSS participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
CTSS participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CTSS participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
CTSS participates in Regulation of CDH1 Expression and FunctionPathwayReactome R-HSA-9764265Inferred only
CTSS participates in Regulation of CDH1 FunctionPathwayReactome R-HSA-9764561Inferred only
CTSS participates in Regulation of Expression and Function of Type I Classical CadherinsPathwayReactome R-HSA-9764274Inferred only
CTSS participates in Regulation of Homotypic Cell-Cell AdhesionPathwayReactome R-HSA-9759476Inferred only
CTSS participates in SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)PathwayReactome R-HSA-9958810Inferred only
CTSS participates in Toll-like Receptor CascadesPathwayReactome R-HSA-168898Inferred only
CTSS participates in Trafficking and processing of endosomal TLRPathwayReactome R-HSA-1679131Inferred only
CTSS regulates positive regulation of cation channel activityBiological processgene ontology P25774|GO:2001259Inferred only
CTSS regulates regulation of antigen processing and presentationBiological processgene ontology P25774|GO:0002577Inferred only

Reactions

15 reactions

MAM01308l+608ATP+1216water608ADP+63L-alanine+27L-arginine+17L-asparagine+36L-aspartate+35L-cysteine+62L-glutamate(1-)+20L-glutamine+13glycine+619proton+16CHEBI:15971

Other names

1 name

Resolves to: CTSS

Also called: Cathepsin S

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+9L-isoleucine

+64L-leucine

+60CHEBI:18019

+7L-methionine

+35L-phenylalanine

+608phosphate(3-)

+24CHEBI:17203

+28L-seryl residue

+29CHEBI:16857

+2L-tryptophan

+19CHEBI:17895

+43L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05259CC BY 4.0Reference data

MAM01343l+422ATP+844water422ADP+34L-alanine+16L-arginine+19L-asparagine+25L-aspartate+3L-cysteine+29L-glutamate(1-)+17L-glutamine+16glycine+434proton+9CHEBI:15971+20L-isoleucine+59L-leucine+26CHEBI:18019+14L-methionine+25L-phenylalanine+422phosphate(3-)+16CHEBI:17203+30L-seryl residue+29CHEBI:16857+3L-tryptophan+9CHEBI:17895+24L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05261CC BY 4.0Reference data

MAM01345l+417ATP+834water417ADP+26L-alanine+7L-arginine+19L-asparagine+24L-aspartate+3L-cysteine+32L-glutamate(1-)+18L-glutamine+24glycine+432proton+13CHEBI:15971+20L-isoleucine+51L-leucine+34CHEBI:18019+10L-methionine+27L-phenylalanine+417phosphate(3-)+19CHEBI:17203+25L-seryl residue+30CHEBI:16857+3L-tryptophan+6CHEBI:17895+27L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05263CC BY 4.0Reference data

MAM01351l+4560ATP+9120water4560ADP+275L-alanine+150L-arginine+247L-asparagine+233L-aspartate+25L-cysteine+298L-glutamate(1-)+230L-glutamine+207glycine+4584proton+115CHEBI:15971+285L-isoleucine+533L-leucine+357CHEBI:18019+79L-methionine+224L-phenylalanine+4560phosphate(3-)+171CHEBI:17203+392L-seryl residue+300CHEBI:16857+37L-tryptophan+151CHEBI:17895+252L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05265CC BY 4.0Reference data

2673ATP+MAM01827l+5346water2673ADP+134L-alanine+134L-arginine+138L-asparagine+176L-aspartate+48L-cysteine+186L-glutamate(1-)+110L-glutamine+262glycine+2747proton+62CHEBI:15971+104L-isoleucine+166L-leucine+154CHEBI:18019+48L-methionine+98L-phenylalanine+2673phosphate(3-)+114CHEBI:17203+278L-seryl residue+182CHEBI:16857+60L-tryptophan+98CHEBI:17895+122L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05272CC BY 4.0Reference data

405ATP+810water+MAM02044l405ADP+30L-alanine+9L-arginine+21L-asparagine+25L-aspartate+12L-cysteine+25L-glutamate(1-)+17L-glutamine+31glycine+411proton+13CHEBI:15971+18L-isoleucine+31L-leucine+35CHEBI:18019+5L-methionine+8L-phenylalanine+405phosphate(3-)+21CHEBI:17203+18L-seryl residue+22CHEBI:16857+8L-tryptophan+21CHEBI:17895+36L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05274CC BY 4.0Reference data

809ATP+1618water+MAM02753l809ADP+37L-alanine+42L-arginine+40L-asparagine+36L-aspartate+48L-cysteine+56L-glutamate(1-)+31L-glutamine+62glycine+810proton+24CHEBI:15971+22L-isoleucine+48L-leucine+49CHEBI:18019+11L-methionine+21L-phenylalanine+809phosphate(3-)+69CHEBI:17203+56L-seryl residue+61CHEBI:16857+19L-tryptophan+30CHEBI:17895+48L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05276CC BY 4.0Reference data

621ATP+1242water+MAM02802l621ADP+42L-alanine+44L-arginine+25L-asparagine+35L-aspartate+26L-cysteine+51L-glutamate(1-)+26L-glutamine+49glycine+634proton+13CHEBI:15971+22L-isoleucine+51L-leucine+29CHEBI:18019+9L-methionine+21L-phenylalanine+621phosphate(3-)+33CHEBI:17203+38L-seryl residue+36CHEBI:16857+14L-tryptophan+21CHEBI:17895+37L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05278CC BY 4.0Reference data

MAM00186l+697ATP+1394water697ADP+61L-alanine+27L-arginine+34L-asparagine+45L-aspartate+40L-cysteine+42L-glutamate(1-)+17L-glutamine+52glycine+699proton+19CHEBI:15971+15L-isoleucine+65L-leucine+58CHEBI:18019+10L-methionine+28L-phenylalanine+697phosphate(3-)+32CHEBI:17203+41L-seryl residue+30CHEBI:16857+8L-tryptophan+26CHEBI:17895+48L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05280CC BY 4.0Reference data

MAM01359l+316ATP+632water316ADP+39L-alanine+34L-arginine+L-asparagine+11L-aspartate+2L-cysteine+40L-glutamate(1-)+32L-glutamine+18glycine+320proton+2CHEBI:15971+2L-isoleucine+41L-leucine+13CHEBI:18019+8L-methionine+4L-phenylalanine+316phosphate(3-)+8CHEBI:17203+14L-seryl residue+12CHEBI:16857+8L-tryptophan+4CHEBI:17895+24L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05282CC BY 4.0Reference data

MAM01350l+266ATP+532water266ADP+23L-alanine+17L-arginine+5L-asparagine+16L-aspartate+30L-glutamate(1-)+19L-glutamine+11glycine+273proton+6CHEBI:15971+41L-leucine+22CHEBI:18019+4L-methionine+8L-phenylalanine+266phosphate(3-)+10CHEBI:17203+16L-seryl residue+12CHEBI:16857+5L-tryptophan+7CHEBI:17895+15L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05284CC BY 4.0Reference data

284ATP+568water+MAM02935l284ADP+21L-alanine+20L-arginine+11L-asparagine+10L-aspartate+5L-cysteine+22L-glutamate(1-)+17L-glutamine+21glycine+277proton+6CHEBI:15971+10L-isoleucine+31L-leucine+19CHEBI:18019+12L-methionine+6L-phenylalanine+284phosphate(3-)+12CHEBI:17203+20L-seryl residue+12CHEBI:16857+5L-tryptophan+4CHEBI:17895+21L-valine

Catalysed by CTSA or CTSG or LGMN or CTSZ or CTSH or CTSC or CTSD or CTSL or CTSV or CTSK or CTSS or CTSB and 5 more alternatives

Reaction pageLeft to rightBalancedlysosome

Human-GEM MAR05285CC BY 4.0Reference data

Show the remaining 3