GDPD5

Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of various proteins, releasing them from the plasma membrane into the extracellular space. Cleaves the GPI-anchor of glypican-6/GPC6, thereby positively regulating neuron differentiation in a cell-autonomous manner. May also hydrolyze the GPI-anchor of glypican-3/GPC3. Cleaves the GPI-anchor of the serine protease inhibitor RECK, leading to its inactivation. RECK inactivation inhibits NOTCH signaling in neighboring cells and induces differentiation of spinal motor neurons (By similarity). RECK inactivation can also regulate amyloid-beta precursor protein (APP) processing by ADAM10. May additionally catalyze the hydrolysis of the phosphodiester bond in sn-glycerol 3-phosphocholine, potentially contributing to osmotic regulation of cellular glycerophosphocholine levels (By similarity)..

Function from UniProtKB (Q8WTR4), read 2026-09-23. CC BY 4.0.