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Proteins/UNIPROT:Q9P2J5
Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing)..
Function from UniProtKB (Q9P2J5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
132 statements
132 statements · 8 reference databases · Subject: LARS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+L-leucine+MAM03073cAMP+MAM02404c+diphosphate(3-)
Catalysed by LARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.4cytosol
Human-GEM MAR05141CC BY 4.0Reference data
CHEBI:78442+L-leucine+ATP(4-)CHEBI:78494+AMP+diphosphate(3-)
Catalysed by
5 names
Resolves to: LARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:11688CC BY 4.0Reference data
CHEBI:78530+waterCHEBI:78442+L-methionine+hydron
Catalysed by LARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:77535CC BY 4.0Reference data