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Proteins/UNIPROT:P30793
Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown..
Function from UniProtKB (P30793), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
82 statements
82 statements · 7 reference databases · Subject: GCH1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
GTP+water7,8-dihydroneopterin 3'-triphosphate+formic acid+proton
Catalysed by GCH1
Reaction pageLeft to rightBalancedEC 3.5.4.16cytosol
Human-GEM MAR04160CC BY 4.0Reference data
GTP+water7,8-dihydroneopterin 3'-triphosphate+formic acid+proton
Catalysed by GCH1
4 names
Resolves to: GCH1
Human-GEM MAR04162CC BY 4.0Reference data
Catalysed by GCH1
Reaction pageLeft to rightBalancedEC 3.5.4.16cytosol
Human-GEM MAR04169CC BY 4.0Reference data
Catalysed by GCH1
Reaction pageLeft to rightBalancedEC 3.5.4.16nucleus
Human-GEM MAR04170CC BY 4.0Reference data
MAM00574c7,8-dihydroneopterin 3'-triphosphate+water
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16cytosol
Human-GEM MAR04817CC BY 4.0Reference data
MAM00574n7,8-dihydroneopterin 3'-triphosphate+water
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16nucleus
Human-GEM MAR04818CC BY 4.0Reference data
MAM00575c+formic acid+protonMAM01832c+water
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16cytosol
Human-GEM MAR04833CC BY 4.0Reference data
MAM00575n+formic acid+protonMAM01832n+water
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16nucleus
Human-GEM MAR04834CC BY 4.0Reference data
MAM00574cMAM00575c
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16cytosol
Human-GEM MAR04835CC BY 4.0Reference data
MAM00574nMAM00575n
Catalysed by GCH1
Reaction pageReversibleBalancedEC 3.5.4.16nucleus
Human-GEM MAR04836CC BY 4.0Reference data
GTP+water7,8-dihydroneopterin 3'-triphosphate+formate+hydron
Catalysed by GCH1
Reaction pageDirection not assertedBalanced
Rhea RHEA:17473CC BY 4.0Reference data