Pathway
Toll-like Receptor Cascades
In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogenic component to TLR initializes signaling pathways that lead to induction of Interferon alpha/beta and inflammatory cytokines. There are two main signaling pathways. The first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRIF(TICAM1)-dependent pathway that is peculiar to TLR3 and TLR4. TLR4-mediated signaling pathway via TRIF requires adapter molecule TRAM (TRIF-related adapter molecule or TICAM2). TRAM is thought to bridge between the activated TLR4 complex and TRIF.. This pathway is organized as trafficking and processing of TLR, various TLR cascades (TLR10,TLR3,TLR5,TLR7/8,TLR9,TLR4,TLR2) and their regulation.
REACT:R-HSA-168898Reactome
What the reference databases state
Statements
167 statements
167 statements · 1 reference database · Subject: Toll-like Receptor Cascades · Sources: Reactome
- AGER participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ALPK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- APOB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- APP participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ATF1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ATF2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- BIRC2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- BIRC3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- BPI participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- BTK participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- BTRC participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CASP8 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
Show the remaining 155
- CD14 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CD180 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CD36 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CHUK participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CNPY3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CTSB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CTSK participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CTSL participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CTSS participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CTSV participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- CUL1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DNM1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DNM2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DNM3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DUSP3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DUSP4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DUSP6 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- DUSP7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ECSIT participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- EEA1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ELK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FADD participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FBXW11 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FGA participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FGB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FGG participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- FOS participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- GSDMD participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- GSDME participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- HMGB1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- HSP90B1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IKBIP participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IKBKB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IKBKE participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IKBKG participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRAK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRAK2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRAK3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRAK4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRF3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRF5 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- IRF7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ITGAM participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- ITGB2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- JUN participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- LBP participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- LGMN participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- LRRC14 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- LY86 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- LY96 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP2K1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP2K3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP2K4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP2K6 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP2K7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP3K1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP3K7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAP3K8 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK10 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK11 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK14 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK8 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPK9 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPKAPK2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MAPKAPK3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MEF2A participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MEF2C participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- MYD88 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- N4BP1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NFKB1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NFKB2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NFKBIA participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NFKBIB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NKIRAS1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NKIRAS2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NLRC5 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NLRX1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NOD1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- NOD2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- OPTN participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PELI1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PELI2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PELI3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PIK3C3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PIK3R4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PLCG2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PPP2CA participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PPP2CB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PPP2R1A participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PPP2R1B participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PPP2R5D participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PTPN11 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- PTPN4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RBSN participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RELA participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RIPK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RIPK2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RIPK3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RPS27A participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RPS6KA1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RPS6KA2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RPS6KA3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- RPS6KA5 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- S100A1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- S100A12 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- S100A8 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- S100A9 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- S100B participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SAA1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SFTPA1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SFTPA2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SFTPD participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SIGIRR participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SKP1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SLC15A4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- SOCS1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TAB1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TAB2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TAB3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TANK participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TBK1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TICAM1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TICAM2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TIFA participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TIRAP participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR10 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR4 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR5 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR6 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR7 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR8 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TLR9 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TNIP2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TP53 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TRAF2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TRAF3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- TRAF6 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBA52 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBB participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBC participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBE2D1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBE2D2 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBE2D3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBE2N participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UBE2V1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- UNC93B1 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- USP14 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- USP18 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only
- VRK3 participates in Toll-like Receptor CascadesProteinReactome R-HSA-168898Inferred only