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Proteins/UNIPROT:O60832
[Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme..
[Isoform 3]: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression..
Function from UniProtKB (O60832), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
65 statements
65 statements · 3 reference databases · Subject: DKC1 · Sources: gene ontology, Hetionet, Reactome
1 reaction
CHEBI:65315CHEBI:65314
Reaction pageDirection not assertedBalanced
Rhea RHEA:47036CC BY 4.0Reference data
7 names
Resolves to: DKC1