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Proteins/UNIPROT:P30519
[Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron..
[Heme oxygenase 2 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron..
Function from UniProtKB (P30519), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
190 statements
190 statements · 6 reference databases · Subject: HMOX2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
3 reactions
5proton+heme b+3NADPH(4-)+3dioxygenbiliverdin IXalpha+CO+iron(2+)+3water+3NADP(3-)
Reaction pageLeft to rightBalancedEC 1.14.14.18cytosol
Human-GEM MAR01450CC BY 4.0Reference data
3
3 names
Resolves to: HMOX2
Reaction pageLeft to rightUnbalancedEC 1.14.14.18cytosol
Human-GEM MAR04763CC BY 4.0Reference data
heme b+3reduced [NADPH--hemoprotein reductase]+3dioxygenbiliverdin IXalpha+CO+iron(2+)+3oxidized [NADPH--hemoprotein reductase]+3water+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21764CC BY 4.0Reference data