GPR142

Highly selective G protein-coupled receptor for aromatic amino acids specifically L-Tryptophan (L-Trp) and L-Phenylalanine (L-Phe), with L-Trp being the most potent and efficacious agonist. GPR142 agonists triggers the activation of both GNAQ/G(q) and GNAI1/G(i)-coupled signaling pathways. L-Trp stimulates glucose-induced insulin secretion and triggers G(q)-mediated signaling (By similarity). GPR142 appears to have a role as a sensor of aromatic essential amino acids controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon but also CCK and incretin in the gastrointestinal-tract, contributing to the control of glucose homeostasis by coordinating pancreatic and gut hormone secretion (By similarity)..

Function from UniProtKB (Q7Z601), read 2026-09-23. CC BY 4.0.