Proteins/UNIPROT:P52757

CHN2

ProteinUNIPROT:P52757

GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.

Function from UniProtKB (P52757), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 3 reference databases · Subject: CHN2 · Sources: gene ontology, Hetionet, Reactome

Order

AKT1 interacts with CHN2ProteinHetionet hetionet:interacts:1124-207Inferred only
CHN2 interacts with BAG6ProteinHetionet hetionet:interacts:1124-7917Inferred only
CHN2 interacts with ERBB3ProteinHetionet hetionet:interacts:1124-2065Inferred only
CHN2 interacts with NCK1ProteinHetionet hetionet:interacts:1124-4690Inferred only
CHN2 interacts with RAC1ProteinHetionet hetionet:interacts:1124-5879Inferred only
CHN2 interacts with RACGAP1ProteinHetionet hetionet:interacts:1124-29127Inferred only
CHN2 interacts with SUMO2ProteinHetionet hetionet:interacts:1124-6613Inferred only
CHN2 interacts with TGFBR1ProteinHetionet hetionet:interacts:1124-7046Inferred only
CHN2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
CHN2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
CHN2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CHN2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only

Show the remaining 9

CHN2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
CHN2 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology P52757|GO:0051056Inferred only
CDC25A increases the expression of CHN2ProteinHetionet hetionet:regulates:993-1124Inferred only
CTSL increases the expression of CHN2ProteinHetionet hetionet:regulates:1514-1124Inferred only
ERAP1 increases the expression of CHN2ProteinHetionet hetionet:regulates:51752-1124Inferred only
ETV1 increases the expression of CHN2ProteinHetionet hetionet:regulates:2115-1124Inferred only
FZD5 increases the expression of CHN2ProteinHetionet hetionet:regulates:7855-1124Inferred only
MGLL increases the expression of CHN2ProteinHetionet hetionet:regulates:11343-1124Inferred only
TIPARP increases the expression of CHN2ProteinHetionet hetionet:regulates:25976-1124Inferred only

Other names

4 names

Resolves to: CHN2

Also called: ARHGAP3BCHBeta-chimerinRho GTPase-activating protein 3

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