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Proteins/UNIPROT:Q7LGC8
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity)..
Function from UniProtKB (Q7LGC8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
34 statements
34 statements · 5 reference databases · Subject: CHST3 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, WikiPathways
8 reactions
MAM02230g+3'-phospho-5'-adenylyl sulfateproton+MAM02278g+adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.21Golgi apparatus
Human-GEM MAR07371CC BY 4.0Reference data
MAM02305g+3'-phospho-5'-adenylyl sulfateproton+MAM02288g+adenosine 3',5'-bismonophosphate
6 names
Resolves to: CHST3
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.21Golgi apparatus
Human-GEM MAR07452CC BY 4.0Reference data
MAM02290g+3'-phospho-5'-adenylyl sulfateproton+MAM02303g+adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.21Golgi apparatus
Human-GEM MAR07481CC BY 4.0Reference data
MAM01568g+23'-phospho-5'-adenylyl sulfateMAM01532g+2proton+2adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST15
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Golgi apparatus
Human-GEM MAR07519CC BY 4.0Reference data
MAM01541g+3'-phospho-5'-adenylyl sulfateMAM01533g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST15
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Golgi apparatus
Human-GEM MAR07522CC BY 4.0Reference data
MAM01552g+3'-phospho-5'-adenylyl sulfateMAM01553g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST15
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Golgi apparatus
Human-GEM MAR07537CC BY 4.0Reference data
MAM01565g+3'-phospho-5'-adenylyl sulfateMAM01567g+proton+adenosine 3',5'-bismonophosphate
Catalysed by CHST3 or CHST7 or CHST15
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Golgi apparatus
Human-GEM MAR07552CC BY 4.0Reference data
CHEBI:57652+n3'-phosphoadenylyl sulfateCHEBI:62065+nadenosine 3',5'-bisphosphate+nhydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11108CC BY 4.0Reference data