Proteins/UNIPROT:O76075

DFFB

ProteinUNIPROT:O76075

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Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.

Function from UniProtKB (O76075), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

196 statements

196 statements · 4 reference databases · Subject: DFFB · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ALOXE3 covaries with DFFBProteinHetionet hetionet:covaries:1677-59344Inferred only
PRDM15 covaries with DFFBProteinHetionet hetionet:covaries:1677-63977Inferred only
APP interacts with DFFBProteinHetionet hetionet:interacts:1677-351Inferred only
DFFB interacts with CAND1ProteinHetionet hetionet:interacts:1677-55832Inferred only
DFFB interacts with CIDEBProteinHetionet hetionet:interacts:1677-27141Inferred only
DFFB interacts with COPS5ProteinHetionet hetionet:interacts:10987-1677Inferred only
DFFB interacts with CUL1ProteinHetionet hetionet:interacts:1677-8454Inferred only
DFFB interacts with CUL2ProteinHetionet hetionet:interacts:1677-8453Inferred only
DFFB interacts with CUL5ProteinHetionet hetionet:interacts:1677-8065Inferred only
DFFA interacts with DFFBProteinHetionet hetionet:interacts:1676-1677Inferred only
DFFB interacts with NEDD8ProteinHetionet hetionet:interacts:1677-4738Inferred only
DFFB interacts with TOP2AProteinHetionet hetionet:interacts:1677-7153Inferred only

Show the remaining 184

DFFB interacts with UBCProteinHetionet hetionet:interacts:1677-7316Inferred only
DFFB participates in Acute viral myocarditisPathwayWikiPathways WP4298Inferred only
DFFB participates in ApoptosisPathwayWikiPathways WP254Inferred only
DFFB participates in ApoptosisPathwayReactome R-HSA-109581Inferred only
DFFB participates in Apoptosis induced DNA fragmentationPathwayReactome R-HSA-140342Inferred only
DFFB participates in Apoptosis modulation and signalingPathwayWikiPathways WP1772Inferred only
DFFB participates in Apoptotic execution phasePathwayReactome R-HSA-75153Inferred only
DFFB participates in Fas ligand pathway and stress induction of heat shock proteinsPathwayWikiPathways WP314Inferred only
DFFB participates in Programmed Cell DeathPathwayReactome R-HSA-5357801Inferred only
DFFB regulates negative regulation of apoptotic DNA fragmentationBiological processgene ontology O76075|GO:1902511Inferred only
DFFB increases the expression of ABHD6ProteinHetionet hetionet:regulates:1677-57406Inferred only
ADGRG1 increases the expression of DFFBProteinHetionet hetionet:regulates:9289-1677Inferred only
DFFB decreases the expression of ADI1ProteinHetionet hetionet:regulates:1677-55256Inferred only
DFFB increases the expression of ADRB2ProteinHetionet hetionet:regulates:1677-154Inferred only
AOC3 increases the expression of DFFBProteinHetionet hetionet:regulates:8639-1677Inferred only
AP2A2 increases the expression of DFFBProteinHetionet hetionet:regulates:161-1677Inferred only
ARL1 increases the expression of DFFBProteinHetionet hetionet:regulates:400-1677Inferred only
ATF6 increases the expression of DFFBProteinHetionet hetionet:regulates:22926-1677Inferred only
DFFB decreases the expression of ATP1B1ProteinHetionet hetionet:regulates:1677-481Inferred only
ATP2A2 increases the expression of DFFBProteinHetionet hetionet:regulates:488-1677Inferred only
ATP5PO decreases the expression of DFFBProteinHetionet hetionet:regulates:539-1677Inferred only
DFFB decreases the expression of BAG3ProteinHetionet hetionet:regulates:1677-9531Inferred only
BBS9 increases the expression of DFFBProteinHetionet hetionet:regulates:27241-1677Inferred only
BLM increases the expression of DFFBProteinHetionet hetionet:regulates:641-1677Inferred only
BLVRA increases the expression of DFFBProteinHetionet hetionet:regulates:644-1677Inferred only
BPHL increases the expression of DFFBProteinHetionet hetionet:regulates:670-1677Inferred only
BRAF increases the expression of DFFBProteinHetionet hetionet:regulates:673-1677Inferred only
DFFB increases the expression of C2CD2ProteinHetionet hetionet:regulates:1677-25966Inferred only
CAMK2G increases the expression of DFFBProteinHetionet hetionet:regulates:818-1677Inferred only
DFFB decreases the expression of CASC3ProteinHetionet hetionet:regulates:1677-22794Inferred only
CASP2 increases the expression of DFFBProteinHetionet hetionet:regulates:835-1677Inferred only
CAVIN1 increases the expression of DFFBProteinHetionet hetionet:regulates:284119-1677Inferred only
CCNA1 increases the expression of DFFBProteinHetionet hetionet:regulates:8900-1677Inferred only
CCNC increases the expression of DFFBProteinHetionet hetionet:regulates:892-1677Inferred only
DFFB decreases the expression of CDC20ProteinHetionet hetionet:regulates:1677-991Inferred only
CENPE increases the expression of DFFBProteinHetionet hetionet:regulates:1062-1677Inferred only
DFFB decreases the expression of CHMP4AProteinHetionet hetionet:regulates:1677-29082Inferred only
COG4 increases the expression of DFFBProteinHetionet hetionet:regulates:25839-1677Inferred only
COQ8A increases the expression of DFFBProteinHetionet hetionet:regulates:56997-1677Inferred only
CSNK1E increases the expression of DFFBProteinHetionet hetionet:regulates:1454-1677Inferred only
CSRP1 increases the expression of DFFBProteinHetionet hetionet:regulates:1465-1677Inferred only
CTSL increases the expression of DFFBProteinHetionet hetionet:regulates:1514-1677Inferred only
CXCL1 increases the expression of DFFBProteinHetionet hetionet:regulates:2919-1677Inferred only
DDR1 increases the expression of DFFBProteinHetionet hetionet:regulates:780-1677Inferred only
DHRS7 increases the expression of DFFBProteinHetionet hetionet:regulates:51635-1677Inferred only
DFFB decreases the expression of DIAPH2ProteinHetionet hetionet:regulates:1677-1730Inferred only
DPF1 increases the expression of DFFBProteinHetionet hetionet:regulates:8193-1677Inferred only
DFFB decreases the expression of DZANK1ProteinHetionet hetionet:regulates:1677-55184Inferred only
ELAC2 increases the expression of DFFBProteinHetionet hetionet:regulates:60528-1677Inferred only
ENO1 increases the expression of DFFBProteinHetionet hetionet:regulates:2023-1677Inferred only
EPB41L2 increases the expression of DFFBProteinHetionet hetionet:regulates:2037-1677Inferred only
ERG increases the expression of DFFBProteinHetionet hetionet:regulates:2078-1677Inferred only
DFFB decreases the expression of ETFBProteinHetionet hetionet:regulates:1677-2109Inferred only
EXOSC8 increases the expression of DFFBProteinHetionet hetionet:regulates:11340-1677Inferred only
FADD increases the expression of DFFBProteinHetionet hetionet:regulates:8772-1677Inferred only
FADS1 increases the expression of DFFBProteinHetionet hetionet:regulates:3992-1677Inferred only
DFFB decreases the expression of FOXJ3ProteinHetionet hetionet:regulates:1677-22887Inferred only
DFFB decreases the expression of FOXO4ProteinHetionet hetionet:regulates:1677-4303Inferred only
FZD4 increases the expression of DFFBProteinHetionet hetionet:regulates:8322-1677Inferred only
G6PD increases the expression of DFFBProteinHetionet hetionet:regulates:2539-1677Inferred only
GCK increases the expression of DFFBProteinHetionet hetionet:regulates:2645-1677Inferred only
GNG5 increases the expression of DFFBProteinHetionet hetionet:regulates:2787-1677Inferred only
GPR101 increases the expression of DFFBProteinHetionet hetionet:regulates:83550-1677Inferred only
GTF2H2 increases the expression of DFFBProteinHetionet hetionet:regulates:2966-1677Inferred only
DFFB increases the expression of HERC6ProteinHetionet hetionet:regulates:1677-55008Inferred only
HEXB increases the expression of DFFBProteinHetionet hetionet:regulates:3074-1677Inferred only
HMGB1 increases the expression of DFFBProteinHetionet hetionet:regulates:3146-1677Inferred only
HPD increases the expression of DFFBProteinHetionet hetionet:regulates:3242-1677Inferred only
HPGD increases the expression of DFFBProteinHetionet hetionet:regulates:3248-1677Inferred only
HS2ST1 increases the expression of DFFBProteinHetionet hetionet:regulates:9653-1677Inferred only
DFFB decreases the expression of HSD17B11ProteinHetionet hetionet:regulates:1677-51170Inferred only
HSD17B11 increases the expression of DFFBProteinHetionet hetionet:regulates:51170-1677Inferred only
HSPA9 increases the expression of DFFBProteinHetionet hetionet:regulates:3313-1677Inferred only
DFFB decreases the expression of IARS2ProteinHetionet hetionet:regulates:1677-55699Inferred only
ID2 increases the expression of DFFBProteinHetionet hetionet:regulates:3398-1677Inferred only
DFFB decreases the expression of IDH1ProteinHetionet hetionet:regulates:1677-3417Inferred only
IL13RA1 increases the expression of DFFBProteinHetionet hetionet:regulates:3597-1677Inferred only
IQGAP1 increases the expression of DFFBProteinHetionet hetionet:regulates:8826-1677Inferred only
ISL1 increases the expression of DFFBProteinHetionet hetionet:regulates:3670-1677Inferred only
ITGA2 increases the expression of DFFBProteinHetionet hetionet:regulates:3673-1677Inferred only
ITGAV increases the expression of DFFBProteinHetionet hetionet:regulates:3685-1677Inferred only
KCNK1 increases the expression of DFFBProteinHetionet hetionet:regulates:3775-1677Inferred only
KCNK2 increases the expression of DFFBProteinHetionet hetionet:regulates:3776-1677Inferred only
DFFB decreases the expression of KDM3AProteinHetionet hetionet:regulates:1677-55818Inferred only
DFFB decreases the expression of KDM5DProteinHetionet hetionet:regulates:1677-8284Inferred only
KISS1R increases the expression of DFFBProteinHetionet hetionet:regulates:84634-1677Inferred only
KLHDC2 increases the expression of DFFBProteinHetionet hetionet:regulates:23588-1677Inferred only
DFFB increases the expression of KLHL21ProteinHetionet hetionet:regulates:1677-9903Inferred only
LANCL1 increases the expression of DFFBProteinHetionet hetionet:regulates:10314-1677Inferred only
LIPH increases the expression of DFFBProteinHetionet hetionet:regulates:200879-1677Inferred only
DFFB decreases the expression of LPGAT1ProteinHetionet hetionet:regulates:1677-9926Inferred only
DFFB decreases the expression of LRPAP1ProteinHetionet hetionet:regulates:1677-4043Inferred only
LRSAM1 increases the expression of DFFBProteinHetionet hetionet:regulates:90678-1677Inferred only
LZIC increases the expression of DFFBProteinHetionet hetionet:regulates:84328-1677Inferred only
MAFG increases the expression of DFFBProteinHetionet hetionet:regulates:4097-1677Inferred only
DFFB increases the expression of MALProteinHetionet hetionet:regulates:1677-4118Inferred only
MAP3K4 increases the expression of DFFBProteinHetionet hetionet:regulates:4216-1677Inferred only
MAPKAPK5 increases the expression of DFFBProteinHetionet hetionet:regulates:8550-1677Inferred only
MCM8 increases the expression of DFFBProteinHetionet hetionet:regulates:84515-1677Inferred only
MDH1 decreases the expression of DFFBProteinHetionet hetionet:regulates:4190-1677Inferred only
MLLT6 increases the expression of DFFBProteinHetionet hetionet:regulates:4302-1677Inferred only
MYF6 increases the expression of DFFBProteinHetionet hetionet:regulates:4618-1677Inferred only
MYOD1 increases the expression of DFFBProteinHetionet hetionet:regulates:4654-1677Inferred only
NDUFS6 increases the expression of DFFBProteinHetionet hetionet:regulates:4726-1677Inferred only
NEK7 increases the expression of DFFBProteinHetionet hetionet:regulates:140609-1677Inferred only
NKX2-3 increases the expression of DFFBProteinHetionet hetionet:regulates:159296-1677Inferred only
NT5E increases the expression of DFFBProteinHetionet hetionet:regulates:4907-1677Inferred only
NXF1 increases the expression of DFFBProteinHetionet hetionet:regulates:10482-1677Inferred only
OTUD7A increases the expression of DFFBProteinHetionet hetionet:regulates:161725-1677Inferred only
P4HA1 increases the expression of DFFBProteinHetionet hetionet:regulates:5033-1677Inferred only
DFFB decreases the expression of PCNAProteinHetionet hetionet:regulates:1677-5111Inferred only
PDX1 increases the expression of DFFBProteinHetionet hetionet:regulates:3651-1677Inferred only
PFKFB3 increases the expression of DFFBProteinHetionet hetionet:regulates:5209-1677Inferred only
DFFB decreases the expression of PGAM1ProteinHetionet hetionet:regulates:1677-5223Inferred only
PHF1 increases the expression of DFFBProteinHetionet hetionet:regulates:5252-1677Inferred only
PHF21B increases the expression of DFFBProteinHetionet hetionet:regulates:112885-1677Inferred only
PIH1D1 increases the expression of DFFBProteinHetionet hetionet:regulates:55011-1677Inferred only
PJA2 increases the expression of DFFBProteinHetionet hetionet:regulates:9867-1677Inferred only
DFFB decreases the expression of PLIN2ProteinHetionet hetionet:regulates:1677-123Inferred only
PLPP1 increases the expression of DFFBProteinHetionet hetionet:regulates:8611-1677Inferred only
PLPP3 increases the expression of DFFBProteinHetionet hetionet:regulates:8613-1677Inferred only
POP4 increases the expression of DFFBProteinHetionet hetionet:regulates:10775-1677Inferred only
PPAT increases the expression of DFFBProteinHetionet hetionet:regulates:5471-1677Inferred only
PROCR increases the expression of DFFBProteinHetionet hetionet:regulates:10544-1677Inferred only
DFFB decreases the expression of PRUNE2ProteinHetionet hetionet:regulates:1677-158471Inferred only
PSPH increases the expression of DFFBProteinHetionet hetionet:regulates:5723-1677Inferred only
DFFB decreases the expression of PTPRAProteinHetionet hetionet:regulates:1677-5786Inferred only
RAB4A increases the expression of DFFBProteinHetionet hetionet:regulates:5867-1677Inferred only
RAF1 increases the expression of DFFBProteinHetionet hetionet:regulates:5894-1677Inferred only
RAN increases the expression of DFFBProteinHetionet hetionet:regulates:5901-1677Inferred only
RASSF2 increases the expression of DFFBProteinHetionet hetionet:regulates:9770-1677Inferred only
RBMX increases the expression of DFFBProteinHetionet hetionet:regulates:27316-1677Inferred only
RET increases the expression of DFFBProteinHetionet hetionet:regulates:5979-1677Inferred only
RIPK1 increases the expression of DFFBProteinHetionet hetionet:regulates:8737-1677Inferred only
RIPK3 increases the expression of DFFBProteinHetionet hetionet:regulates:11035-1677Inferred only
RORC increases the expression of DFFBProteinHetionet hetionet:regulates:6097-1677Inferred only
RPS16 increases the expression of DFFBProteinHetionet hetionet:regulates:6217-1677Inferred only
RPS3A increases the expression of DFFBProteinHetionet hetionet:regulates:6189-1677Inferred only
DFFB decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:1677-6192Inferred only
DFFB increases the expression of RRS1ProteinHetionet hetionet:regulates:1677-23212Inferred only
RUVBL2 increases the expression of DFFBProteinHetionet hetionet:regulates:10856-1677Inferred only
SDHC increases the expression of DFFBProteinHetionet hetionet:regulates:6391-1677Inferred only
DFFB increases the expression of SELLProteinHetionet hetionet:regulates:1677-6402Inferred only
SERPINC1 decreases the expression of DFFBProteinHetionet hetionet:regulates:462-1677Inferred only
DFFB decreases the expression of SETD1AProteinHetionet hetionet:regulates:1677-9739Inferred only
DFFB decreases the expression of SLC25A6ProteinHetionet hetionet:regulates:1677-293Inferred only
SLC36A1 increases the expression of DFFBProteinHetionet hetionet:regulates:206358-1677Inferred only
SNRK increases the expression of DFFBProteinHetionet hetionet:regulates:54861-1677Inferred only
DFFB increases the expression of SNX6ProteinHetionet hetionet:regulates:1677-58533Inferred only
DFFB decreases the expression of SPASTProteinHetionet hetionet:regulates:1677-6683Inferred only
SPP1 increases the expression of DFFBProteinHetionet hetionet:regulates:6696-1677Inferred only
DFFB increases the expression of SQORProteinHetionet hetionet:regulates:1677-58472Inferred only
SRC increases the expression of DFFBProteinHetionet hetionet:regulates:6714-1677Inferred only
SRSF4 increases the expression of DFFBProteinHetionet hetionet:regulates:6429-1677Inferred only
STAT1 increases the expression of DFFBProteinHetionet hetionet:regulates:6772-1677Inferred only
DFFB increases the expression of STK10ProteinHetionet hetionet:regulates:1677-6793Inferred only
STMN1 increases the expression of DFFBProteinHetionet hetionet:regulates:3925-1677Inferred only
TBC1D15 increases the expression of DFFBProteinHetionet hetionet:regulates:64786-1677Inferred only
TBC1D31 increases the expression of DFFBProteinHetionet hetionet:regulates:93594-1677Inferred only
DFFB decreases the expression of TBPProteinHetionet hetionet:regulates:1677-6908Inferred only
TCIRG1 increases the expression of DFFBProteinHetionet hetionet:regulates:10312-1677Inferred only
THBD increases the expression of DFFBProteinHetionet hetionet:regulates:7056-1677Inferred only
TLE1 increases the expression of DFFBProteinHetionet hetionet:regulates:7088-1677Inferred only
DFFB increases the expression of TLR4ProteinHetionet hetionet:regulates:1677-7099Inferred only
TNFRSF18 increases the expression of DFFBProteinHetionet hetionet:regulates:8784-1677Inferred only
TNIP1 increases the expression of DFFBProteinHetionet hetionet:regulates:10318-1677Inferred only
TOLLIP increases the expression of DFFBProteinHetionet hetionet:regulates:54472-1677Inferred only
TPI1 increases the expression of DFFBProteinHetionet hetionet:regulates:7167-1677Inferred only
TRAF5 increases the expression of DFFBProteinHetionet hetionet:regulates:7188-1677Inferred only
DFFB decreases the expression of TUBA1AProteinHetionet hetionet:regulates:1677-7846Inferred only
TUBD1 increases the expression of DFFBProteinHetionet hetionet:regulates:51174-1677Inferred only
TXNRD1 increases the expression of DFFBProteinHetionet hetionet:regulates:7296-1677Inferred only
UROD increases the expression of DFFBProteinHetionet hetionet:regulates:7389-1677Inferred only
USF1 increases the expression of DFFBProteinHetionet hetionet:regulates:7391-1677Inferred only
USP14 increases the expression of DFFBProteinHetionet hetionet:regulates:9097-1677Inferred only
DFFB decreases the expression of USP22ProteinHetionet hetionet:regulates:1677-23326Inferred only
USP22 increases the expression of DFFBProteinHetionet hetionet:regulates:23326-1677Inferred only
USP7 increases the expression of DFFBProteinHetionet hetionet:regulates:7874-1677Inferred only
WASHC5 increases the expression of DFFBProteinHetionet hetionet:regulates:9897-1677Inferred only
YME1L1 increases the expression of DFFBProteinHetionet hetionet:regulates:10730-1677Inferred only
ZNF562 increases the expression of DFFBProteinHetionet hetionet:regulates:54811-1677Inferred only
ZNF610 increases the expression of DFFBProteinHetionet hetionet:regulates:162963-1677Inferred only
ZNF623 increases the expression of DFFBProteinHetionet hetionet:regulates:9831-1677Inferred only
ZPBP2 increases the expression of DFFBProteinHetionet hetionet:regulates:124626-1677Inferred only

Other names

9 names

Resolves to: DFFB

Also called: CADCaspase-activated deoxyribonucleaseCaspase-activated DNaseCaspase-activated nucleaseCPANDFF-40DFF2DFF40DNA fragmentation factor 40 kDa subunit

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