Compound
a ganglioside GM3 (d18:1(4E))
A carbohydrate acid derivative anion that is the conjugate base of α-N-acetylneuraminosyl-(2→3)-β-D-galactosyl-(1→4)-β-D-glucosylceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:60065), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C42H72N2O21R
- Mass
- 941.022 g/mol
- Charge
- -1
- SMILES
- *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- NEU1ProteinUNIPROT:Q99519substrate ofInferred only69 paths23 endpoints
- NEU3ProteinUNIPROT:Q9UQ49substrate ofInferred only56 paths14 endpoints
- GLB1ProteinUNIPROT:P16278substrate ofInferred only41 paths41 endpoints
- B4GALNT1ProteinUNIPROT:Q00973substrate ofInferred only33 paths11 endpoints
- NEU4ProteinUNIPROT:Q8WWR8substrate ofInferred only30 paths10 endpoints
- NEU2ProteinUNIPROT:Q9Y3R4substrate ofInferred only28 paths14 endpoints
- CTSAProteinUNIPROT:P10619substrate ofInferred only26 paths26 endpoints
- ST8SIA1ProteinUNIPROT:Q92185substrate ofInferred only24 paths8 endpoints
- GALNSProteinUNIPROT:P34059substrate ofInferred only14 paths14 endpoints
- ST8SIA4ProteinUNIPROT:Q92187substrate ofInferred only12 paths12 endpoints
- ST8SIA3ProteinUNIPROT:O43173substrate ofInferred only10 paths10 endpoints
- ST8SIA6ProteinUNIPROT:P61647substrate ofInferred only10 paths10 endpoints
What the reference databases state
Statements
24 statements
24 statements · 2 reference databases · Subject: a ganglioside GM3 (d18:1(4E)) · Sources: Human-GEM, Rhea
- a ganglioside GM3 (d18:1(4E)) is a substrate of B4GALNT1ProteinRhea RHEA:12588Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of B4GALNT1ProteinHuman-GEM MAR08190Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of B4GALNT1ProteinHuman-GEM MAR00827Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of CTSAProteinHuman-GEM MAR12065Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of GALNSProteinHuman-GEM MAR12065Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of GLB1ProteinHuman-GEM MAR12065Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR00826Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR00825Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR12065Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR00825Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR00826Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU3ProteinRhea RHEA:47900Inferred only
Show the remaining 12
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR00825Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR00826Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR12070Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU4ProteinHuman-GEM MAR00825Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU4ProteinHuman-GEM MAR00826Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of NEU4ProteinRhea RHEA:47900Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA1ProteinRhea RHEA:41760Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA1ProteinHuman-GEM MAR00841Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA1ProteinHuman-GEM MAR08179Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA3ProteinRhea RHEA:41760Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA4ProteinHuman-GEM MAR12087Inferred only
- a ganglioside GM3 (d18:1(4E)) is a substrate of ST8SIA6ProteinRhea RHEA:41760Inferred only
Reactions
25 reactions
CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM3 (d18:1(4E))+proton
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00824CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18lysosome
Human-GEM MAR00826CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+MAM03110ca ganglioside GM2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92cytosol
Human-GEM MAR00827CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00828CC BY 4.0Reference data
MAM02013l+waterMAM02012l+a ganglioside GM3 (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00836CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD3 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00841CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD3 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8Golgi apparatus
Human-GEM MAR08179CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM3 (d18:1(4E))+proton
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9Golgi apparatus
Human-GEM MAR08184CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+MAM03110ga ganglioside GM2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92Golgi apparatus
Human-GEM MAR08190CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR12044CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525l
Catalysed by HEXA & HEXB & GM2A
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR12061CC BY 4.0Reference data
Other names
4 names
Resolves to: a ganglioside GM3 (d18:1(4E))
- Also called
- alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramideGanglioside GM3 (d18:1(4E))GM3(d18:1(4E))α-N-acetylneuraminosyl-(2→3)-β-D-galactosyl-(1→4)-β-D-glucosylceramide