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a ganglioside GT1a (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

9 compounds within 3 steps: 1 in 1, 2 in 2, 6 in 3

Does it reach a compound?

One step

a ganglioside GQ1b (d18:1(4E))Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST8SIA1cytosol

Two steps

N-acetyl-beta-neuraminic acidReach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GQ1b)
Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 1 morecytosolOne of 2 routes
a ganglioside GT1b (d18:1(4E))Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. exo-alpha-sialidase (GQ1b)
Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 1 morecytosolOne of 2 routes

Three steps

pyruvateReach from here →
Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 2 morecytosol
aldehydo-N-acetyl-D-mannosamineReach from here →

Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 2 more

cytosol

N-glycoloylneuraminateReach from here →

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
exo-alpha-sialidase (GQ1b)
CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 1 morecytosol

CMP-N-acetyl-beta-neuraminateReach from here →

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
exo-alpha-sialidase (GQ1b)
CTP:N-acetylneuraminate cytidylyltransferase

Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 2 morecytosol, nucleusOne of 2 routes

a ganglioside GQ1balpha (d18:1(4E))Reach from here →

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
exo-alpha-sialidase (GQ1b)
a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)

Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 2 morecytosol

a ganglioside GD1b (d18:1(4E))Reach from here →

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
exo-alpha-sialidase (GQ1b)
exo-alpha-sialidase (GT1b)

Catalysed by ST8SIA1, NEU4, NEU1, NEU3 and 1 morecytosolOne of 2 routes