a ganglioside GM3 (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

228 compounds within 3 steps: 5 in 1, 17 in 2, 206 in 3

One step

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GM3)
Catalysed by NEU4, NEU1, NEU3, NEU2cytosolOne of 3 routes
N-acetylneuraminateReach from here →
1. a ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate
Catalysed by NEU4, NEU3
N-acetyl-beta-neuraminic acidReach from here →
1. exo-alpha-sialidase (GM3)
Catalysed by NEU4, NEU1, NEU3, NEU2cytosolOne of 4 routes
a ganglioside GM2 (d18:1(4E))Reach from here →
1. beta-1,4-N-acetyl-galactosaminyltransferase (GM3)
Catalysed by B4GALNT1cytosolOne of 3 routes
a ganglioside GD3 (d18:1(4E))Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST8SIA1cytosolOne of 4 routes

Two steps

CHEBI:1146900Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
2. solute carrier (acetyl-CoA)
Catalysed by ST8SIA1, SLC33A1cytosolOne of 2 routes
pyruvateReach from here →
1. exo-alpha-sialidase (GM3)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))

Three steps

Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosolOne of 3 routes

aldehydo-N-acetyl-D-mannosamineReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol

a globoside Gb3Cer (d18:1(4E))Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosolOne of 3 routes

D-glucosyl-N-acylsphingosineReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, lysosome

a ganglioside Ac-O-7-GD3(d18:1(4E))Reach from here →

Catalysed by ST8SIA1, CASD1cytosol

a ganglioside GA2 (d18:1(4E))Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosolOne of 5 routes

alpha-D-galactoseReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, lysosome

N-acetyl-beta-D-galactosamineReach from here →

Catalysed by B4GALNT1, HEXA, HEXBcytosol

N-glycoloylneuraminateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2cytosol

an isogloboside iGb3Cer (d18:1(4E))Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol

CMP-N-acetyl-beta-neuraminateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol, nucleusOne of 2 routes

a ganglioside GM1 (d18:1(4E))Reach from here →

Catalysed by B4GALNT1, B3GALT4cytosolOne of 3 routes

beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol

a ganglioside GT3 (d18:1(4E))Reach from here →

Catalysed by ST8SIA1, ST8SIA5cytosolOne of 3 routes

a ganglioside GD2 (d18:1(4E))Reach from here →

Catalysed by B4GALNT1, ST8SIA1cytosolOne of 4 routes

Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 more

cytosol, extracellular space

One of 2 routes

an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

acetoacetateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol, mitochondrial matrixOne of 4 routes

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a globoside MSGGReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

a globoside DSGGReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

(7Z)-octadecenoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

CHEBI:15345Reach from here →

Catalysed by ST8SIA1, SLC33A1, AACScytosolOne of 2 routes

cholineReach from here →

Catalysed by ST8SIA1, SLC33A1, CHATcytosol, nucleus

acetylpyruvateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol

all-trans-retinoic acidReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 morecytosol, extracellular spaceOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by ST8SIA1, SLC33A1, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by ST8SIA1, SLC33A1, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1BcytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, GLYATcytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by ST8SIA1, SLC33A1, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

oleoyl-CoAReach from here →

Catalysed by ST8SIA1, SLC33A1, CPT1A, CPT1C and 1 morecytosolOne of 11 routes