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Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
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Reactions
Reach

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A reference for what the literature reports. Not medical advice.

Reaction

2',3'-cGAMP+water5'-pGpA(2'-5')+hydron

Left to right · Balanced

Inferred

Reference data, not a finding. Evidence key

Catalysts

SMPDL3A

Kinetics

Km 31 µM · 2',3'-cGAMP · SMPDL3A
Measured · human enzyme; other conditions not stated
UniProt Q92484 · 2026_03 · CC BY 4.0 · paper cited by UniProt PMID 37890481

Rhea RHEA:78339·2026-08-19·CC BY 4.0Reference data

2',3'-cGAMP+water→5'-pGpA(2'-5')+hydron

Catalysts

Kinetics

2',3'-cGAMP+water5'-pGpA(2'-5')+hydron