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Proteins/UNIPROT:Q92484
Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity..
Function from UniProtKB (Q92484), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 5 reference databases · Subject: SMPDL3A · Sources: Bgee, gene ontology, Hetionet, Rhea, UniProt
4 reactions
4 names
Resolves to: SMPDL3A
Rhea RHEA:13065CC BY 4.0Reference data
a ribonucleoside 5'-triphosphate+watera ribonucleoside 5'-diphosphate+hydrogenphosphate+hydron
Catalysed by ENTPD3 or ENTPD1 or ENTPD8 or SMPDL3A or NTPCR or ENTPD7 or DDX20 or ENTPD4 or ENTPD2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23680CC BY 4.0Reference data
2',3'-cGAMP+water5'-pGpA(2'-5')+hydron
Catalysed by SMPDL3A
Reaction pageLeft to rightBalanced
Rhea RHEA:78339CC BY 4.0Reference data
5'-pGpA(2'-5')+waterCHEBI:228271+hydrogenphosphate
Catalysed by SMPDL3A
Reaction pageLeft to rightBalanced
Rhea RHEA:78343CC BY 4.0Reference data