leukotriene C4

Three steps

• methanethiolReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 more

• octan-1-olReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 14 routes

• ureaReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC7A6, ARG1cytosol, extracellular spaceOne of 6 routes

• dimethylarsinateReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 more

• L-cystineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 9 routes

• 11-cis-retinolReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by BAAT, DGAT1, LRAT, AWAT1 and 2 morecytosol, peroxisome

• (R)-3-aminoisobutyric acidReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC3A2, SLC7A5, SLC7A10, AGXT2cytosol, extracellular space, mitochondrial matrix

• iodideReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 12 routes

• oxaloacetateReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by BAAT, ACLYcytosol, peroxisome

• nitric oxideReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC7A6, NOS3, NOS1, NOS2cytosol, extracellular spaceOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GATM, ACY1cytosol

• 2-phenylacetamideReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC7A5, EPXcytosol, extracellular space

• D-alanyl-D-alanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of D-alanine and glycine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular space

• CHEBI:16633Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SCLYcytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A5, MARS1cytosol, extracellular space

• (S)-lactateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 15 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A5, AADATcytosol, extracellular spaceOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A5, CNDP2cytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SDS and 1 morecytosol, extracellular spaceOne of 5 routes

• tryptamineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A5, DDCcytosol, extracellular space

• 2-oxoglutaramateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A5, KYAT1cytosol, extracellular spaceOne of 3 routes

• formaldehydeReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1B1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosolOne of 3 routes

• creatineReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GATM, GAMTcytosolOne of 2 routes

• ferrocytochrome cReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 moremitochondrial matrix, cytosol

• oxalic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. glycine:oxygen oxidoreductase (deaminating)
  3. Glyoxylate:oxygen oxidoreductase

  Catalysed by DAO, HAO1cytosol, peroxisomeOne of 3 routes

• (R)-lactaldehydeReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO1B1, GLO1, GLOD4, ADH1C and 6 moreextracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. leukotriene C4 hydrolysis
  2. L-Arginine:glycine amidinotransferase
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GATM, OATcytosol, mitochondrial matrix

• dehydroascorbic acidReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• anilineReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by BAAT, NAT2, NAT1cytosol, peroxisome

• CHEBI:17312Reach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by BAATcytosol, peroxisomeOne of 2 routes

• CHEBI:17380Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A5, SLC7A6, PRODH2cytosol, extracellular spaceOne of 2 routes

• agmatineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by SLC7A6cytosol, extracellular space, mitochondrial matrix

• AH2Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOScytosol, extracellular spaceOne of 4 routes

• indole-3-pyruvateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by SLC7A5, IL4I1cytosol, extracellular spaceOne of 3 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 2 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. leukotriene C4 hydrolysis
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by BAAT, HADHA, ACADVL, HADHBcytosol, peroxisome, mitochondrial matrix

• xanthineReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17724Reach from here →
  1. transport of GSH and leukotriene C4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLCO1B1, BHMT, BHMT2extracellular space, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. leukotriene C4 hydrolysis
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, AARS1cytosol, extracellular space

• glycine betaineReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 3 routes

• trans-urocanateReach from here →
  1. leukotriene C4 hydrolysis
  2. transport of glycine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A6, HALcytosol, extracellular space