2-oxo-3-sulfanylpropanoate

Three steps

• pyridoxine 5'-phosphateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GOT2, GOT1, SLC7A5, SCLYcytosol, extracellular space

• 3-disulfanyl-L-alanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. thioredoxin-disulfide reductase (NADPH) (cystine)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by GOT2, GOT1, TXNRD1, TXNRD3 and 2 morecytosol

• N-glycoloylneuraminateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by MPST, TST, NPLcytosol

• a carboxylateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by MPST, TST, FAHD1cytosol

• L-ascorbic acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by MPST, TSTD1, CLIC1, GSTO1 and 1 more

• Ca(2+)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  3. Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)

  Catalysed by GOT2, GOT1, SLC1A1, SLC24A1 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Phe-tRNA(Phe)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, FARSB and 1 morecytosol, extracellular space

• Gly-tRNA(Gly)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• Trp-tRNA(Trp)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, WARS1cytosol, extracellular space

• Ile-tRNA(Ile)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, IARS1cytosol, extracellular space

• Gln-tRNA(Gln)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• isocyanateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of citrulline and cysteine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by GOT2, GOT1, SLC7A6, LACC1cytosol, extracellular space

• Asn-tRNA(Asn)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of asparagine and cysteine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, NARS1cytosol, extracellular space

• glycocholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space, peroxisomeOne of 8 routes

• cholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. solute carrier organic anion transporter (cholate)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• D-aspartateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GOT2, GOT1, SLC1A1, SLC1A7 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-aspartateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. L-Cysteine:oxygen oxidoreductase
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by GOT2, GOT1, CDO1, SLC25A12 and 1 morecytosol, mitochondrial matrixOne of 33 routes

• CHEBI:30249Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by GOT2, GOT1, SLC7A5, IDO1 and 2 morecytosol, extracellular space

• oxalateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC26A2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by MPST, TST, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 9 routes

• maleateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by GOT2, GOT1, SLC6A14cytosol, extracellular spaceOne of 6 routes

• adipic acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• (indol-3-yl)acetateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by MPST, SQOR, DHODH

• an alcoholReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, CP, PRDX6

• isocitric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by MPST, TST, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by MPST, TST, PC, GOT2cytosol, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by GOT2, GOT1cytosol, extracellular spaceOne of 2 routes

• L-lysineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by GOT2, GOT1, SLC7A9, SLC3A1 and 1 morecytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by GOT2, GOT1, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by GOT2, GOT1, SLC7A6, SLC3A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• D-arginineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by GOT2, GOT1, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by MPST, TST, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 5 routes

• methylarsonateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GSTO1 and 1 morecytosol

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by GOT2, GOT1, SLC7A5, IL4I1cytosol, extracellular space

• tetra-mu3-sulfido-tetrairon(2+)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. De novo synthesis of 2Fe2S
  3. Synthesis of 4Fe4S from 2Fe2S

  Catalysed by GOT2, GOT1, NDUFAB1, FDXR and 11 morecytosol, mitochondrial matrix

• serotoninReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by GOT2, GOT1, SLC7A5, BCAT2 and 1 morecytosol, extracellular space

• 2-oxohexanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by MPST, TST, AGXT2cytosol

• D-cysteineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by GOT2, GOT1, SLC7A5, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• an organic disulfideReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by MPST, SUMF1

• L-alpha-aminobutyric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by MPST, TST, AGXT2, GPTcytosol

• 5-aminolevulinateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 3 morecytosol, extracellular space

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1, SLC7A5, BCAT1cytosol, extracellular spaceOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1, SLC7A5, TATcytosol, extracellular spaceOne of 3 routes