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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Compound

2-(1-hydroxyethyl)thiamine diphosphate

A thiamine phosphate having a 1-hydroxyethyl substituent at the 2-position on the thiazolium ring and an O-diphosphate moiety.

Definition from ChEBI (CHEBI:978), read 2026-09-23. CC BY 4.0.

CHEBI:978ChEBI

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What it touches on the way

Inferred

Not reported; assembled from reference reactions.

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

PDHA1ProteinUNIPROT:P08559substrate ofInferred only38 paths38 endpoints
DLATProteinUNIPROT:P10515substrate ofInferred only32 paths32 endpoints
PDHBProteinUNIPROT:P11177substrate ofInferred only21 paths21 endpoints
PDHA2ProteinUNIPROT:P29803substrate ofInferred only15 paths15 endpoints

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: 2-(1-hydroxyethyl)thiamine diphosphate · Sources: Human-GEM

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2-(1-hydroxyethyl)thiamine diphosphate is a substrate of DLATProteinHuman-GEM MAR20069Inferred only
2-(1-hydroxyethyl)thiamine diphosphate is a substrate of PDHA1ProteinHuman-GEM MAR20069Inferred only
2-(1-hydroxyethyl)thiamine diphosphate is a substrate of PDHA2ProteinHuman-GEM MAR20069Inferred only
2-(1-hydroxyethyl)thiamine diphosphate is a substrate of PDHBProteinHuman-GEM MAR20069Inferred only

Reactions

4 reactions

proton+pyruvate+thiamine(1+) diphosphate2-(1-hydroxyethyl)thiamine diphosphate+carbon dioxide
Catalysed by PDHA1 & PDHB or PDHB & PDHA2
Reaction pageLeft to rightBalancedEC 1.2.4.1GO:0005759
Human-GEM MAR08746CC BY 4.0Reference data
2-(1-hydroxyethyl)thiamine diphosphate+MAM02393mMAM02869m+thiamine(1+) diphosphate
Catalysed by PDHA1 & DLAT & PDHB or DLAT & PDHB & PDHA2
Reaction pageLeft to rightBalancedGO:0005759
Human-GEM MAR20069CC BY 4.0Reference data
CHEBI:58476+thiamine diphosphate2-(1-hydroxyethyl)thiamine diphosphate+pyruvate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24805CC BY 4.0Reference data
2-(1-hydroxyethyl)thiamine diphosphate+2-oxobutanoateCHEBI:49256+thiamine diphosphate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:33691CC BY 4.0Reference data

Other names

3 names

Resolves to: 2-(1-hydroxyethyl)thiamine diphosphate

Also called: 2-(alpha-Hydroxyethyl)thiamine diphosphate2-Hydroxyethyl-ThPP
Systematic name: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethyl)-5-(2-diphosphoethyl)-4-methyl-1,3-thiazol-3-ium