maleate

Three steps

• nicotinic acid D-ribonucleotideReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC25A14, SLC25A30, SLC22A6, QPRTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-carbamoyl-L-aspartic acidReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC25A14, SLC25A30, CADinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:15971Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• androsteroneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• L-cystineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by SLC25A14, SLC25A30, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:16284Reach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. dATP:pyruvate 2-O-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLRinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• iodideReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC26A4inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ubiquinonesReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SDHD and 3 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• L-valineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-arginineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:16497Reach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLRinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• protein polypeptide chainReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosol

• pregnenoloneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, Golgi apparatus, cytosolOne of 4 routes

• 3-fumarylpyruvateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, FAHD1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:16857Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ferrocytochrome cReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SUOXinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• N-acetyl-L-aspartateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC25A14, SLC25A30, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• L-isoleucineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC25A14, SLC25A30, SLC26A6, CLTRN and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• itaconateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. citrate hydro-lyase (cis-aconitate-forming)
  3. cis-aconitate carboxy-lyase

  Catalysed by SLC25A1, ACO2, ACOD1inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• estroneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• propanoateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A14, SLC25A30, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• enol-oxaloacetateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. Citrate Transport, Mitochondrial
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A1, SDHB, SDHAinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, Golgi apparatusOne of 3 routes

• glycine betaineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• urateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• butanoateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SLC25A14, SLC25A30, STS, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• thiocyanateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, FAHinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• dTTPReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A1, PKM, PKLRinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:18095Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, CLTRN and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A14, SLC25A30, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• hydrogen cyanideReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A14, SLC25A30, MPST, TSTinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A1, ACLY, AGXT2inner side of the membrane, outer side of the membrane, cytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. transport of citrate and PEP (cytosol to mitochondria)
  3. N-acetylneuraminate synthase

  Catalysed by SLC25A1, NANSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC6A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• a quinolReach from here →
  1. maleate(in) + citrate(out) = maleate(out) + citrate(in)
  2. Citrate Transport, Mitochondrial
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A1, SDHB, SDHAinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• hypochlorous acidReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC25A14, SLC25A30, SLC26A6, LPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC26A6, SLC12A2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• K(+)Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A14, SLC25A30, SLC1A7, SLC1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC25A14, SLC25A30, DARS1inner side of the membrane, outer side of the membrane, cytosol

• hydrogen sulfideReach from here →
  1. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A14, SLC25A30, SLC26A1, SLC25A10inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes