L-aspartate

Two steps

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Steryl-Sulfatase

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by NAT8L, HADHA, ACADVL, HADHBmitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AGXT2, AARS1cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A13, TPH1, TPH2inner side of the membrane, outer side of the membrane

• 4-methyl-2-oxopentanoateReach from here →
  1. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A13, BCAT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• CHEBI:17895Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and tyrosine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• CHEBI:17927Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by NAT8Lmitochondrial matrix, cytosol

• 3-oxopropanoic acidReach from here →
  1. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  2. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by GAD2, ABATcytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A13, GOT2, TATinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASS1, ASLcytosolOne of 8 routes

• CHEBI:18019Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by ASNS, SLC7A6cytosol, extracellular spaceOne of 18 routes

• CHEBI:18095Reach from here →
  1. Aspartate Intake by System Asct-1 Transporter
  2. prolyl 4-hydroxylase (AKG)

  Catalysed by P4HA2, P4HB, P4HA1extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• 2-phenylethylamineReach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A13, DDCinner side of the membrane, outer side of the membrane, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A13, PFASinner side of the membrane, outer side of the membrane, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A13, SLC7A8inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by GOT2, AGXT2mitochondrial matrixOne of 7 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AGXT2

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by NAT8L, HADHA, ACAA2, HADHBmitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by NAT8L, HADHA, ACADVL, HADHBmitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by NAT8L, HADHA, ACADVL, HADHBmitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by NAT8L, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by NAT8L, ECHS1, ACAA2, HADHmitochondrial matrixOne of 2 routes

• folic acidReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Folate Transport by Oats

  Catalysed by SLC25A14, SLC25A30, SLC22A8, SLC22A7inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by NAT8L, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A13, TPH1, TPH2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by NAT8L, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYcytosol

• 3-disulfanyl-L-alanineReach from here →
  1. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  2. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A13, CTHinner side of the membrane, outer side of the membrane, cytosol

• a dicarboxylateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30, SLC25A35, SLC25A34inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. transport of aspartate (cytosol to extracellular)
  2. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 6 moreextracellular space, cytosolOne of 3 routes

• Phe-tRNA(Phe)Reach from here →
  1. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A13, FARSB, FARSAinner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A13, WARS1inner side of the membrane, outer side of the membrane, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A13, QARS1inner side of the membrane, outer side of the membrane, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by ASNS, NARS1cytosol

• chlorine(.)Reach from here →
  1. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  2. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by ASNS, SLC6A14cytosol, extracellular spaceOne of 22 routes

• D-aspartateReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• acetateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. N-Acetyl-L-aspartate amidohydrolase

  Catalysed by NAT8L, ASPA, ACY3mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A13, IDO1, TDO2, IDO2inner side of the membrane, outer side of the membrane, cytosol

• oxalateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30, SLC26A2, SLC26A6 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by GOT2, CSmitochondrial matrixOne of 2 routes

• maleateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLC25A14, SLC25A30, SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  2. (S)-dihydroorotate amidohydrolase

  Catalysed by CADcytosolOne of 2 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by GOT2mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes