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Proteins/UNIPROT:P13674
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins..
Function from UniProtKB (P13674), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
249 statements
249 statements · 5 reference databases · Subject: P4HA1 · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
4 reactions
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HB & P4HA1 or P4HA2 & P4HB
Reaction pageLeft to rightBalancedEC 1.14.11.2endoplasmic reticulum
Human-GEM MAR01649CC BY 4.0Reference data
3 names
Resolves to: P4HA1
Reaction pageLeft to rightBalancedEC 1.14.11.2cytosol
Human-GEM MAR04776CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+CHEBI:17203carbon dioxide+succinate(2-)+CHEBI:18095
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalancedEC 1.14.11.2mitochondrial matrix
Human-GEM MAR04777CC BY 4.0Reference data
L-prolyl-[collagen]+2-oxoglutarate(2-)+dioxygentrans-4-hydroxy-L-prolyl-[collagen]+succinate(2-)+carbon dioxide
Catalysed by P4HA2 or P4HA1 or P4HA3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18945CC BY 4.0Reference data