indole-3-pyruvate

Three steps

• a 3-acylpyruvateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by AADAT, AGXT, AGXT2, FAHD1

• (S)-malyl-CoAReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by AADAT, CLYBL, SUCLG1, SUCLA2

• glutaryl-CoAReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

• propanoyl-CoAReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by AADAT, CLYBL

• prostaglandin F2alphaReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 4 routes

• D-alanineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by AADAT, SLC7A5, PIPOXextracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by AADAT, SLC7A5, SHMT1, SHMT2extracellular space, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by AADAT, SLC7A6, ASLextracellular space, cytosolOne of 6 routes

• 4-guanidinobutanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by AADAT, SLC7A6, GATMextracellular space, cytosol

• L-dopaReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by AADAT, SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by AADAT, SLC7A6, GATMextracellular space, cytosol

• L-histidineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by AADAT, SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-ornithineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by AADAT, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by AADAT, SLC7A5, GLYATL3, GLYAT and 1 moreextracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by AADAT, SLC7A5, GOT2, GOT1extracellular space, cytosolOne of 4 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by AADAT, AGXT, AGXT2

• guanidinoacetateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by AADAT, SLC7A5, GATMextracellular space, cytosolOne of 5 routes

• 3',5'-cyclic GMPReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• D-threonineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by AADAT, SLC22A6, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• L-dopaquinoneReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by AADAT, SLC7A5, TYRextracellular space, cytosol

• glutathioneReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by AADAT, SLC7A5, GSSextracellular space, cytosol

• L-threonineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 9 routes

• L-saccharopineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by AADAT, SLC7A6, AASSextracellular space, cytosol, mitochondrial matrix

• L-kynurenineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  3. arylformamidase (L-formylkynurenine)

  Catalysed by AADAT, IDO1, TDO2, IDO2 and 1 morecytosolOne of 8 routes

• beta-alanineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by AADAT, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• leukotriene C4Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by AADAT, SLC7A5extracellular space, cytosol

• taurocyamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by AADAT, SLC7A6, GATMextracellular space, cytosol

• L-glutamate 5-semialdehydeReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by AADAT, SLC7A6, OATextracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by AADAT, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• 3-hydroxy-L-kynurenineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by AADAT, SLC7A5, KYNUextracellular space, cytosol

• 3',5'-cyclic AMPReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by AADAT, SLC7A5, GCLC, GCLMextracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by AADAT, SLC7A6extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by AADAT, SLC7A5, BHMT2extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)

  Catalysed by AADAT, SLC7A5, CADextracellular space, cytosolOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by AADAT, SLC7A5, BHMT2extracellular space, cytosol

• L-tyrosineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 6 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, SLC7A5, AGXT2extracellular space, cytosolOne of 13 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AADAT, SLC7A5, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• histamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by AADAT, SLC7A6, HDCextracellular space, cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by AADAT, SLC7A13, PAICSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by AADAT, SLC7A6, IL4I1extracellular space, cytosol

• S-sulfanyl-L-cysteineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by AADAT, SLC7A5, CARS2extracellular space, cytosol

• (3S)-citramalyl-CoAReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by AADAT, AGXT, AGXT2, CLYBL

• L-2-aminoadipateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by AADAT

• 5-phospho-beta-D-ribosylamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by AADAT, SLC7A5, PPATextracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by AADAT, SLC7A5, GFPT2, GFPT1extracellular space, cytosol