sulfite

Three steps

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by SLC25A10, CLYBL, AADATmitochondrial matrix, cytosol

• CHEBI:17895Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 10 routes

• all-trans-retinalReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• butanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

  Catalysed by SUOX, STS, SLC22A9mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• ubiquinolReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. succinate:quinone oxidoreductase
  3. thioredoxin-disulfide reductase (NADPH) (ubiquinone)

  Catalysed by SLC25A10, SDHD, SDHB, SDHA and 3 moremitochondrial matrix, cytosolOne of 7 routes

• 3-phenylpyruvateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by MPST, TST, KYAT1cytosolOne of 2 routes

• CHEBI:18019Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• L-glutamineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC3A2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• 5-hydroxyisourateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. urate:oxygen oxidoreductase

  Catalysed by TSTD1, SLC22A13inner side of the membrane, outer side of the membrane, cytosol

• dTTPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by MPST, TST, AGXT2, SLC1A4cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• N-carbamoyl-beta-alanineReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• S-methylmercury-L-cysteineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by MPST, TST, AGXT2, BCKDHA and 1 morecytosol, mitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by MPST, TST, SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SUOX, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 3 routes

• (S)-lactoyl-AMPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 5 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol

• 3-demethylubiquinone-10Reach from here →
  1. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  2. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)
  3. 3-demethylubiquinone-10 + NADH + 2 H(+) = 3-demethylubiquinol-10 + NAD(+)

  Catalysed by SQOR, COQ3, RTN4IP1One of 2 routes

• tauroursodeoxycholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• glycoursodeoxycholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• glycochenodeoxycholate 3-sulfateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TSTD1, ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• deoxycholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• dimethylarsinous acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by TSTD1, AS3MT

• CHEBI:240943Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SUOX, SLC26A6, SLC6A5mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SUOX, SLC26A6, LPOmitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6, SLC12A2, SLC12A1mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• trimethylarsineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by TSTD1, AS3MT

• selenomethionineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• 5(S)-HETEReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• 3-mercaptolactic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHB, LDHC and 2 morecytosol

• 2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by MPST, TST, AGXT2cytosol

• CHEBI:28666Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. Persulfide dioxygenase
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by MPST, TST, AGXT2, SCLYcytosol, mitochondrial matrix

• N-glycoloylneuraminateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by MPST, TST, NPLcytosol

• iron(2+)Reach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2 and 5 moreinner side of the membrane, outer side of the membrane

• a carboxylateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by MPST, TST, FAHD1cytosol

• K(+)Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SUOX, SLC25A14, SLC25A30, SLC1A7 and 4 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SUOX, SLC25A14, SLC25A30, DARS1mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• a thiolReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by MPST, TST, SUMF1cytosol

• glycolateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by SLC25A10, CLYBL, GRHPRmitochondrial matrix, cytosol

• orotateReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. a quinone + succinate = fumarate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SLC25A10, SDHB, DHODHmitochondrial matrix, cytosol