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Proteins/UNIPROT:Q8WWV3
NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3. Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro. However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo. May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (By similarity). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity)..
Function from UniProtKB (Q8WWV3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
16 statements
16 statements · 5 reference databases · Subject: RTN4IP1 · Sources: Bgee, gene ontology, Hetionet, Rhea, WikiPathways
4 reactions
a 3-demethylubiquinone+NADH(2-)+2hydrona 3-demethylubiquinol+NAD(1-)
Catalysed by RTN4IP1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:83235CC BY 4.0Reference data
a 3-demethylubiquinone+NADPH(4-)+2hydrona 3-demethylubiquinol+NADP(3-)
Catalysed by RTN4IP1
Reaction pageDirection not assertedBalance undeterminable
4 names
Resolves to: RTN4IP1
Rhea RHEA:83239CC BY 4.0Reference data
3-demethylubiquinone-10+NADH(2-)+2hydron3-demethylubiquinol-10+NAD(1-)
Catalysed by RTN4IP1
Reaction pageDirection not assertedBalanced
Rhea RHEA:83243CC BY 4.0Reference data
3-demethylubiquinone-10+NADPH(4-)+2hydron3-demethylubiquinol-10+NADP(3-)
Catalysed by RTN4IP1
Reaction pageDirection not assertedBalanced
Rhea RHEA:83247CC BY 4.0Reference data