iron(2+)

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

450 compounds within 3 steps: 4 in 1, 58 in 2, 388 in 3

One step

Fe(3+)Reach from here →
1. Fe(II):oxygen oxidoreductase
Catalysed by CP, FTH1, FXN, FTMT and 1 moreextracellular spaceOne of 3 routes
di-mu-sulfido-diiron(2+)Reach from here →
1. De novo synthesis of 2Fe2S
Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix
L-alanineReach from here →
1. De novo synthesis of 2Fe2S
Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix
heme bReach from here →
1. Ferrochelatase, Mitochondrial
Catalysed by FECHmitochondrial matrixOne of 3 routes

Two steps

CHEBI:1146900Reach from here →
1. De novo synthesis of 2Fe2S
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix
N(omega)-methyl-L-arginineReach from here →
1. De novo synthesis of 2Fe2S
2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

pyruvateReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrixOne of 14 routes

CHEBI:15570Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix, cytosol

L-leucineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

CHEBI:15699Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

CHEBI:15971Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-cystineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrix, extracellular space, cytosol

(R)-3-aminoisobutyric acidReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

L-citrullineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-valineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

L-arginineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

protein polypeptide chainReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 3 moremitochondrial matrix, cytosol

CHEBI:16633Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, cytosol

CHEBI:16857Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

L-isoleucineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

CHEBI:17203Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

dehydroascorbic acidReach from here →

Catalysed by CP, FTH1, FXN, FTMT and 2 moreextracellular space

COReach from here →

Catalysed by FECH, HMOX1, HMOX2mitochondrial matrix, cytosolOne of 2 routes

AH2Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

L-cysteineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 11 routes

Ala-tRNA(Ala)Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, cytosol

CHEBI:17895Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

CHEBI:18019Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-glutamineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 6 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

CHEBI:18095Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosol

2-aminoisobutanoateReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

N(omega),N('omega)-dimethyl-L-arginineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

pyridoxine 5'-phosphateReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, cytosol

chlorine(.)Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-aspartateReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

tetra-mu3-sulfido-tetrairon(2+)Reach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix

D-cysteineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

D-serineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

L-ornithineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

gamma-Glu-AlaReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 9 moremitochondrial matrix, extracellular space, cytosol

deoxyhemoglobinReach from here →

Catalysed by FECHmitochondrial matrix, cytosol

glycineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 5 moremitochondrial matrixOne of 9 routes

D-alanineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

D-threonineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

L-methionineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 7 routes

L-tryptophanReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

L-threonineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

L-kynurenineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix

beta-alanineReach from here →

Catalysed by NDUFAB1, FDXR, FXN, FDX2 and 4 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

biliverdin IXalphaReach from here →

Catalysed by FECH, HMOX1, HMOX2mitochondrial matrix, cytosolOne of 2 routes