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3-demethylubiquinone-10

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

16 compounds within 3 steps: 2 in 1, 3 in 2, 11 in 3

Does it reach a compound?

One step

ubiquinonesReach from here →
1. Methyltransferase Coq3
Catalysed by COQ3mitochondrial matrix
3-demethylubiquinol-10Reach from here →
1. 3-demethylubiquinone-10 + NADH + 2 H(+) = 3-demethylubiquinol-10 + NAD(+)
Catalysed by RTN4IP1One of 2 routes

Two steps

ubiquinolReach from here →
1. Methyltransferase Coq3
2. thioredoxin-disulfide reductase (NADPH) (ubiquinone)
Catalysed by COQ3, NQO1, CBR1mitochondrial matrix, cytosolOne of 7 routes
fumaric acidReach from here →
1. Methyltransferase Coq3
2. succinate:quinone oxidoreductase
Catalysed by COQ3, SDHD, SDHB, SDHA and 1 moremitochondrial matrix

Three steps

a quinoneReach from here →
Catalysed by COQ3, SDHD, SDHB, SDHA and 1 moremitochondrial matrix
(S)-malateReach from here →
Catalysed by COQ3, and 2 more

Reach from here →

3-demethylubiquinone-10 + NADH + 2 H(+) = 3-demethylubiquinol-10 + NAD(+)
3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

Catalysed by RTN4IP1, COQ3

mitochondrial matrix, cytosol

One of 5 routes

sulfateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
transport of fumarate and sulfate (cytosol to mitochondria)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix

ferrocytochrome cReach from here →

Methyltransferase Coq3
thioredoxin-disulfide reductase (NADPH) (ubiquinone)
ubiquinol:ferricytochrome-c oxidoreductase

Catalysed by COQ3, NQO1, CBR1, UQCRQ and 9 moremitochondrial matrix, cytosol, mitochondrial intermembrane space

sulfiteReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
transport of fumarate and sulfite (cytosol to mitochondria)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

4-fumarylacetoacetateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix

thiosulfateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
transport of fumarate and thiosulfate (cytosol to mitochondria)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

2-(N(omega)-L-arginino)succinateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

N(6)-(1,2-dicarboxyethyl)-AMPReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Catalysed by COQ3, SDHD, SDHB, SDHA and 3 moremitochondrial matrix, cytosolOne of 2 routes

(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →

Methyltransferase Coq3
succinate:quinone oxidoreductase
1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

Catalysed by COQ3, SDHD, SDHB, SDHA and 2 moremitochondrial matrix, cytosolOne of 2 routes