methylglyoxal

1. 2-Oxopropanal:NADP+ oxidoreductase

No catalyst recordedcytosol

1. (R)-Lactaldehyde:NAD+ oxidoreductase

No catalyst recordedcytosolOne of 2 routes

1. aldose reductase (methylglyoxal)

Catalysed by AKR7A2, AKR1A1, AKR1B1cytosolOne of 2 routes

1. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

Catalysed by GLO1, GLOD4cytosolOne of 2 routes

1. dihydroxyacetone phosphate = methylglyoxal + phosphate

Catalysed by TPI1

1. 2-Oxopropanal:NADP+ oxidoreductase
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

1. 2-Oxopropanal:NADP+ oxidoreductase
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)

No catalyst recordedcytosol, mitochondrial matrixOne of 4 routes