What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- hydroxyacetone has the functional parent acetoneCompoundChEBI CHEBI:27957Inferred only
Statements
3 statements
3 statements · 1 reference database · Subject: hydroxyacetone · Sources: Human-GEM
- hydroxyacetone is converted to methylglyoxalCompoundHuman-GEM MAR08499Inferred only
- methylglyoxal is converted to hydroxyacetoneCompoundHuman-GEM MAR08497Inferred only
- hydroxyacetone is metabolised by CYP2E1ProteinHuman-GEM MAR08499Inferred only
Reactions
12 reactions
proton+methylglyoxal+NADPH(4-)hydroxyacetone+NADP(3-)
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2GO:0005829
Human-GEM MAR08497CC BY 4.0Reference data
acetone+proton+NADPH(4-)+dioxygenwater+hydroxyacetone+NADP(3-)
Catalysed by CYP2E1
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005829
Human-GEM MAR08498CC BY 4.0Reference data
proton+hydroxyacetone+NADPH(4-)+dioxygen2water+methylglyoxal+NADP(3-)
Catalysed by CYP2E1
Reaction pageLeft to rightBalancedEC 1.14.14.1GO:0005829
Human-GEM MAR08499CC BY 4.0Reference data
proton+hydroxyacetone+NADPH(4-)NADP(3-)+propane-1,2-diol
Catalysed by AKR7A2 or AKR1B1 or AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.21, 1.1.1.2GO:0005829
Human-GEM MAR08500CC BY 4.0Reference data
hydroxyacetone+NADP(3-)methylglyoxal+NADPH(4-)+hydron
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:27986CC BY 4.0Reference data
hydroxyacetone+NADH(2-)+hydronCHEBI:29002+NAD(1-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:28667CC BY 4.0Reference data
hydroxyacetone+NAD(1-)methylglyoxal+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:35615CC BY 4.0Reference data
D-ribulose 5-phosphate+L-tyrosineCHEBI:140647+hydroxyacetone+formaldehyde+hydrogenphosphate+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:45732CC BY 4.0Reference data
acetone+NADH(2-)+dioxygen+hydronhydroxyacetone+NAD(1-)+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:55788CC BY 4.0Reference data
D-ribulose 5-phosphate+L-tryptophanCHEBI:140652+hydroxyacetone+formaldehyde+hydrogenphosphate+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56696CC BY 4.0Reference data
CHEBI:176527hydroxyacetone+sulfite+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:68604CC BY 4.0Reference data
CHEBI:195439+NAD(1-)+waterhydroxyacetone+ammonium+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:76795CC BY 4.0Reference data